The cytoskeleton refers to the structure of the protein fiber network in eukaryotic cells. The objective existence of cytoskeleton was not recognized until the 1960s, when electron microscopy samples were fixed at room temperature using glutaraldehyde. CD BioSciences offers our clients a wide range of cytoskeleton research services, including imaging, compound screening, and mechanistic studies, based on our extensive experience in cell biology.
The concept of cytoskeleton in a narrow sense refers to the protein-fiber reticulum system (a system of microtubules, microfilaments, and intermediate fibers) in eukaryotic cells, which consists of a structural system called the cytoskeletal system, together with the intracellular genetic system, the biofilm system and the "three systems of the cell".
All three types of cytoskeletons are chemically composed of proteins, structurally all are fibrous can support the shape of the cell, involved in intracellular material transport and information transfer; all can play an important role in cell movement and cell division. However, their physiological functions as well as composition still differ.
| Microfilaments | Microtubules | Intermediate Filaments | |
|---|---|---|---|
| Composition | Actin | α, β, γ Microtubulin | Multiple Heterologous Fibrillar Proteins |
| Polarity | Yes | Yes | - |
| Enzymatic Activity | ATPase Active Site | GTPase Active Site | None |
| Auxiliary Protein | Actin-binding Protein | Kinesin, Kinesin, Microtubule-binding Protein | None |
| Distribution | Prevalent in Eukaryotic Cells | Present in all Eukaryotic Cells | Tissue Specificity |
| Function | Muscle contraction, cell motility, maintenance of cell morphology, involvement in cell division, associated with cell signaling. | Maintenance of cell morphology, maintenance of the localized distribution of organelles, components of ciliary flagellar motility, spindle formation and chromosome movement. | Cellular support, transport of mRNA in the cytoplasm, intracellular signaling, formation of continuous structures between adjacent cells, involved in cell differentiation. |
| Drug specificity | Cytochalasin, Phalloidin | Colchicine, Paclitaxel | None |
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CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
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