Cytoskeletal Interaction Research Service

The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences uses cytoskeleton mechanical properties research tools and technical resources to save you more time in your studies. Also use powerful assay kits and mathematical models of mechanical properties to optimize your protocols and obtain high quality experimental data.

Cytoskeletal Interaction

• Actin-Microtubule Crosstalk in Cell Migration
  Complex biochemical, biophysical, and genomic studies have demonstrated that many changes can occur to facilitate or regulate cell movement. Actin and microtubules regulate the rate of cell migration by controlling the assembly and disassembly of integrin-mediated adhesions. This additional regulation of actomyosin contractility and microtubule acetylation coordinated the attachment and detachment of cells from their surroundings by controlling integrin receptor density and activation/adhesion maturation to affect ligand interactions and matrix assembly.

Crosstalk between actomyosin contractility and microtubule acetylation ^[1].

• Actin-Microtubule Crosstalk during Branching Morphogenesis
  The salivary gland provides a powerful model system for elucidating branching morphogenesis. Actin contractility and microtubule acetylation control the levels of fibronectin and α5β1 integrin in the developing salivary gland.

Actin-Microtubule Crosstalk during Branching Morphogenesis ^[1].

Cytoskeleton-organelle Interactions

The live cell imaging approach further reveals that organelles are highly dynamic in the cytoplasm. Indeed, organelles move around the cytoplasm, change their size, and shape, and establish transient connections with each other, all under precise regulatory control. Small organelles in the cytoplasm, including mitochondria, lysosomes, etc., all move under the regulation of the cytoskeleton. For example, myosins influence the distribution of lysosomes within the cytoplasm, microtubule provides tracks for the movement of mitochondria in the cell, etc. Organelles and cytoskeleton interact with each other and together participate in the physiological activities of the cell.

Our Services

The cytoskeleton controls the location of organelles within the cell and provides the mechanical power for intracellular transport, and together they participate in many physiological processes in the cell. CD BioSciences offers a variety of high-resolution imaging platforms, together with our fluorescent probes, to help our clients investigate the mechanisms by which the cytoskeleton interacts with various intracellular components.

• Cell Migration & Invasion Assay Service
• Cytoskeletal Interaction Assay Service in Mitosis
• Organelle Transport Research Service
• Computational Modeling Service for Cytoskeletal Interactions

Our Advantages

CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.

Reference

1. Joo E E, et al. Post-polymerization crosstalk between the actin cytoskeleton and microtubule network[J]. Bioarchitecture, 2016, 6(3): 53-59.

For research use only. Not intended for any clinical use.

Related Services