The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences is committed to developing cutting-edge protein modification technologies and has established a mature protein modification development platform, which can provide high-quality protein PTMs detection services according to the needs of our customers. We insist on providing high-quality related services to our customers, providing one-stop services such as information consultation, design and implementation of detailed experimental protocols.
Protein post-translational modifications (PTMs) are the processes of chemical modification of proteins during or after translation. PTMs are processes that increase the functional diversity of the proteome by adding functional groups such as phosphate, acetate, amide or methyl groups to proteins. Protein post-translational modifications play a key role in many cellular processes, such as cell differentiation, protein degradation, signaling and regulatory processes, regulation of gene expression, and protein interactions. Protein post-translational modifications PTMs typically include phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and protein hydrolysis.
When a protein undergoes some post-translational modification, as the sequence information and molecular weight are determined, the molecular weight of the modified peptide is also determined, and the peptide with the modification is then detected in mass spectrometry detection.
| PTM | Function |
|---|---|
| Phosphorylation | Alters protein morphology; activates/inactivates catalytic activity |
| Ubiquitination | Degradation of target proteins |
| Glycosylation | Directs the protein to its destination |
| Acetylation | Affects protein conformation and its affinity for other proteins |
| Lipidation | Affects the activity and subcellular location of proteins |
| Methylation | Affects protein composition and its affinity for other proteins |
| Protein hydrolysis | Removes peptide sequences or regulatory domains |
The cytoskeleton, including microtubules, actin filaments and intermediate filaments, consists of some of the most important and abundant proteins in the cell, which are the primary targets of PTM. The major structural components of the cytoskeleton undergo various PTMs, usually on almost every reactive residue on the protein surface.
Chemical structures of posttranslational modifications (PTMs) [1].
Common protein modifications in organisms include phosphorylation, glycosylation, acetylation, ubiquitination, etc. CD BioSciences provides the most comprehensive services for post-translational modifications of cytoskeletal proteins. Through strict monitoring and effective execution, we are committed to providing the most valuable solutions to complete your project.
Microtubules PTM Detection Service
Actins PTM Detection Service
Intermediate Filaments PTM Detection Service
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CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
For research use only. Not intended for any clinical use.
