| Modification |
Known Sites on Actin (*=known functionally important modification) |
| Acetylation |
Met-1*, Asp/Glu-2*, Asp-3*, Lys-50, Lys-61, Lys-68, Lys-191, Lys-326, Lys-328 |
| ADP-Ribosylation |
Arg-28, Arg-95*, Thr-148*, Arg-177*, Arg-206*, Arg-372* |
| Arginylation |
Asp-3*, Ser-52, Ile-87, Phe-90, Gly-152, Leu-295, Asn-299 |
| Carbonylation |
His-40, His-87, His-173, Cys-374* |
| Crosslinking |
Lys-50 (with Glu-270) * |
| Glutathionylation |
Cys-217, Cys-374* |
| Isoaspartylation |
Asp-25, Asp-179 |
| Malonylation |
Lys-61 |
| Methylation |
His-73*, Ile-87, Asn-299, Lys-326 |
| Nitration |
Tyr-53, Tyr-69*, Tyr-91, Tyr-198, Tyr-218, Tyr-240, Tyr-294, Tyr-362 |
| Nitrosylation |
Cys-217, Cys-257, Cys-285, Cys-374* |
| O-GlcNAcylation |
Ser-52, Ser-155, Ser-199, Ser-232, Ser-323, Ser-368 |
| Oxidation |
Met-44*, Met-47, Trp-79, Met-82, Trp-86, Met-178, Met-190, Cys-217, Met-227, Cys-257, Met-269, Cys-272*, Cys-285*, Met-325, Trp-340, Met- 355, Trp-356, Cys-374* |
| Phosphorylation |
Ser-14, Ser-33, Ser-52, Tyr-53*, Ser-60, Thr-66, Tyr-69, Thr-89, Tyr-91, Thr-148, Thr-160, Thr-162, Tyr-166, Tyr-169, Thr-186, Tyr-188, Tyr-198, Ser-199, Thr/Ser-201*, Thr-202*, Thr-203*, Tyr-218*, Thr-229, Ser- 233, Ser-239, Tyr-240, Thr-262, Tyr-294, Thr-297, Tyr-306, Thr-318, Ser- 323, Ser-324, Tyr-362, Ser-365 |
| SUMOylation |
Lys-68*, Lys-284* |
| Transglutamination |
Gln-41* |
| Ubiquitylation |
Lys-50, Lys-61, Lys-68, Lys-84, Lys-113, Lys-118, Lys-191, Lys-291, Lys- 315, Lys-326, Lys-328 |
