All intermediate filament proteins undergo many post-translational modifications. Recent advances in proteomics and intermediate filament biology have increased the understanding of how post-transcriptional modifications regulate intermediate filament function. CD BioSciences is committed to developing cutting-edge intermediate filaments post-translational modification detection services, and has established a mature PTMs detection platform to provide high-quality protein modification-related services according to customer needs.
Post-translational Modifications of Intermediate Filaments
In contrast to the conserved rod structural domains, the N-terminal and C-terminal structural domains are the source of the large sequence variability observed in the IF protein family and are therefore thought to be responsible for the cell-specific functions of different IF proteins. These domains are also targets of different post-translational modifications, with a large number of post-translational modification motifs. Indeed, many of the novel functions of intermediate filaments emerge in response to the observed changes in post-translational modification status.
Major Post-translational Modifications of Intermediate Filaments
- Phosphorylation
Promotes keratin solubility and rearrangement in cells; prevents proteolytic cleavage of vimentin.
- Farnesylation
Required for vimentin homotypic interactions and overall architecture.
- Sumoylation
Promotes keratin solubility and rearrangement in cells; promotes vimentin solubility.
- Acetylation
Decreases keratin solubility; required for perinuclear keratin network.
Major PTMs of intermediate filament proteins [1].
Our Services
Common intermediate filaments protein modifications in organisms include phosphorylation, glycosylation, acetylation, etc. CD BioSciences provides the most comprehensive services for post-translational modifications of intermediate filament proteins Through strict monitoring and effective execution, we are committed to providing the most valuable solutions to complete your project.
- Detection of Intermediate Filament Protein PTM
- Identification of Protein Profile through LC-MS/MS
- PTM Detection of Intermediate Filaments from Different Species
Process of LC-MS/MS
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- MacTaggart B, et al. Posttranslational modifications of the cytoskeleton[J]. Cytoskeleton, 2021, 78(4): 142-173.
For research use only. Not intended for any clinical use.
