Centrosomal Protein-related Services

Centrosome is the cell organelle formed from proteins and mRNAs. The complete functions of centrosome are mainly dependent on the structure and the large quantity of centrosomal proteins. CD BioSciences offers high-quality and professional centrosomal protein-related service for research use. With advanced technology, equipment, and experienced scientists, we have assisted our global customers in the field of centrosome research.

Introduction into Centrosomal Protein

Plentiful proteins are contained in centrosome. Some of them are involved in the nucleation of the microtubules, such as NEDD1 and PCM1. And some of them regulate the localization of γ-tubulin ring complexes (γ-TuRCs) to the centrosomes. There are also centrosomal proteins play role as kinase, which increase the rate of nucleation and the capacity of nucleation of other centrosomal proteins. Centrosomal proteins influence the functions of centrosome through diverse mechanisms, including stabilizing and destabilizing the microtubule, as well as its dynamics.

Centrosomal Proteins and Centrosome Structure

The centrosome is constituted by a pair of mother and daughter centrioles, which is surrounded by PCMs. Additionally, the PCMs are divided into outer, middle, and inner PCMs according to its localization. These centrosomal proteins play important roles during the process of mitosis, including the bipolar spindle assembly, mitotic entry and exit, centrosome mutation and separation, sister chromatid separation and initiation of genotoxic stress response.

Centrosomal Proteins and their functions (Yi Luan, et al.2021)

Centrosomal Proteins and Cell Cycle

During the duplication of centrosome, multiple proteins are involved and the duplication of centrosome occurs along with the cell mitosis. Centrosome disassembly happens from late mitosis to the early G1 phase, which is regulated by Plk1, CDK1, PCM, separase, and astrin. Then the initiation of centriole duplication occurs, and it needs the activity of CDK and Plk4. After that, the procentriole elongation occurs, in which α/β-tubulin dimers nucleate at γ-TuSC, and the CP110, CPAP, and hPOC5 are necessary for procentriole length and centriole assembly. Then, the separation process begins in the early M phase and it's mediated by Aurora-A, Plk1, CDK1, and Nek2a. At the end, the separated centrosomes assemble the bipolar mitotic spindle for cell division.

Our Services

For assisting out global customers making better progress in the field of centrosomal protein research, CD BioSciences provides comprehensive and professional centrosomal protein-related services.

Protein Purification

Protein Expression

Protein Identification

PPI Analysis

Protein Imaging

PTM Analysis

Protein Engineering

Structure Determination

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Yi Luan, et al. Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors? Biomedicine & Pharmacotherapy, 2021, 0753-3322.

Our services are for research use only and not for any clinical use.