Centrosomal Protein Engineering Service

Centrosomal proteins are localized in centrosomes, and effect the function, structure and other biological processes of centrosomes. As the main microtubule organizing center (MTOC) of most cells, the centrosome abnormity (CA) is highly correlated to malignant tumor. CD BioSciences offers high-quality and professional centrosomal protein engineering service for research use and therapeutic development. With advanced technology, equipment, and experienced scientists, we have assisted our global customers in the field of centrosome research.

Introduction into Centrosomal Protein Engineering

Protein engineering is the process of developing protein with desired properties and functions, and it has contributed a lot in understanding of protein folding and recognition for protein design principles. Generally, there are two strategies of protein engineering: rational protein design and directed evolution. The rational protein design is based on the knowledge of well-known protein's structure and mechanism. For protein with limited information, the directed evolution is more practical.

Outline of protein engineering (J B, et al. 2019)

Centrosome is formed with a pair of centrioles that are embedded in the pericentriolar material (PCM). The PCM supplies sites for nucleation of microtubule and the power of cell division. The complex functions and stable structure of centrosome mainly relies on the centrosomal proteins. During the cell cycle, centrosomal proteins are involved in mitosis entry, mitosis exit, bipolar spindle assembly, centrosome mutation and separation, chromatid separation and so on.

The centrosomal protein abnormity causes CA, which is frequently observed in malignant tumor, including breast, colon, prostate. and lung carcinomas. And the aberrations can be detected with the use of antibodies that target the PCM, such as tubulin. Therefore, centrosomal proteins are potential target for malignant tumor. With the protein engineering technology, centrosomal proteins with desired properties and functions can be designed and constructed.

Our Service

For assisting our global customers making better progress in the field of centrosomal protein research, CD BioSciences offers centrosomal protein engineering service. With our rich experience and advanced technology in protein engineering, we provide customized services based on both rational engineering and directed evolution.

Rational Design

CD BioSciences offers rational design with the process starts with choosing suitable protein scaffold, identifying important modifications, screening of mutants.

Directed Evolution

CD BioSciences offers directed evolution service for our global customers to obtain centrosomal proteins of desired traits.

Semi-Rational Design

CD BioSciences offers semi-rational design which is the combination of rational design and directed evolution that provides a comprehensive method of centrosomal protein engineering.

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

References

1. J B, et al. Evolutionary approaches in protein engineering towards biomaterial construction. RSC Adv. 2019 Oct 29;9(60):34720-34734.
2. Qing R, Hao S, Smorodina E, Jin D, Zalevsky A, Zhang S. Protein Design: From the Aspect of Water Solubility and Stability. Chem Rev. 2022 Sep 28;122(18):14085-14179.

Our services are for research use only and not for any clinical use.