Centrosomal Gene Engineering Service

Centrosome gene are divided into three classes: gene encoding proteins of the centrosomal core structure, gene encoding mRNAs and proteins that compose the pericentriolar material and genes encoding factors that regulate PCM recruitment at the interphase-mitosis transition. CD BioSciences offers high-quality and professional gene editing services of centrosomal genes. With advanced technology, equipment and experienced scientists, we have assisted our global customers in the field of centrosome research.

Overview of Centrosomal Genes

Centrosome is the main microtubule organizing center (MTOC) in most animal cells, which is of great importance for fundamental cellular functions, such as the formation of bipolar spindles, cell division during mitosis, organizing microtubules and transporting mitochondria to their functional destinations. Genes that encoding proteins forming centrosome structure or localized in pericentromeric material (PCM) are called centrosomal genes, which play very important role in many biological processes. For example, overexpression of Aurora B results in multinucleate cells, and the overexpression of Plk4 causes centrosome amplification, which leads to tumorigenesis. Ploidy alteration is one of the most common mechanisms of centrosome anomalies in cancer, and multiple stimuli induce polyploidy and centrosome aberrations, including the inactivation of BRCA1, BRCA2, SKP2, and GADD45 genes. Therefore, the proteins encoded by the centrosomal genes are of great value as potential therapeutic targets of cancers.

Applications of Centrosomal Gene Editing

Centrosomal gene editing animal models are valuable for functional studies of centrosomal genes, as well as therapeutic development of centrosome-related diseases, especially cancers. 3% of all human protein-coding genes encode proteins localized to the centrosome or the centriolar satellites. And Gene Ontology (GO)-based analysis of genes encoding proteins that localize to centrosomes or centriolar satellites shows the enrichment of terms are related to organization of the microtubule cytoskeleton, ciliogenesis, cell cycle progression, and organization of organelles. With gene engineering technology, the DNA makeup can be altered, including point mutation, gene knockout, gene knockin, floxed allele insertion, gene labeling and so on. And they have been applied in a large range of fields for meeting the demands of producers and customers.

Applications of centrosomal gene editing are included but not limited as follows:

• Gene functions and other molecular biological research of centrosomal genes.
• Generation of centrosome-related disease model, such as cancers and ciliopathies.
• Generation of centrosome-targeting drug testing model.

Our Services

CD BioSciences provides comprehensive and professional centrosomal gene engineering services in multiple organisms, as well as customized services based on our years of experience and advanced gene engineering technology. For assisting our global customers making better progresses in centrosome-related research, we provide gene engineering services in organisms including but not limited as follows.

Cell Lines

Dictyostelium

C. elegans

Xenopus

Rodent Animals

Drosophila

Zebrafish

Plants

Yeast

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Yi Luan, et al. Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors? Biomedicine & Pharmacotherapy, 2021, 0753-3322.

Our services are for research use only and not for any clinical use.