Centrosomal Gene Engineering Service in Cell Lines

Inquiry

Centrosome is an organelle that plays role as microtubule organizing center (MTOC). And it's highly associated with many biology processes such as mitosis and cytoskeleton. CD BioSciences offers high-quality and professional gene editing services of centrosomal genes in cell lines. With advanced technology, equipment and experienced scientists, we have assisted our global customers in the field of centrosome research.

Introduction into Centrosomal Genes

Centrosome is comprised of a pair of centrioles which are cylinders formed by nine microtubule triplets with a highly conserved radial symmetry. This cell organelle is involved in many cell biology processes including organization of cytoskeleton, regulation of cell cycle and many processes of protein regulation. Centrosomal genes regulate the assembling of centrosomes and spindle, as well as the composition of the pericentriolar materials (PCMs). Moreover, the abnormality of centrosome causes serious outcomes, such as malignant tumor, brain disease and ciliopathies. Besides, several oncogenic and tumor suppressor proteins localize in centrosome, which indicates that their deregulation might cause centrosomal abnormality.

Introduction into Centrosomal Genes

Methods of Gene Editing in Cell Lines

The cell lines are powerful tools in many fields, such as study of gene function, study of biological mechanism study and manufacturing of biosynthetic products. They are cultured animal cells propagated repeatedly and sometimes indefinitely. CRISPR/Cas systems are high-efficient gene editing systems rely on two main components: guide RNA (gRNA) and CRISPR-related (Cas) nucleases. With CRISPR/Cas system, it's possible to introduce any genetic modification effectively at nearly any position within the genome and minimize off-target effects.

Our Service

With the fully tested technical expertise in gen editing and centrosome research, CD BioSciences provide gene engineering services in cell lines of various members of centrosomal genes meeting our customers requirement. The parental cells we provide gene editing services in are included but not limited as follows.

Cell Line	Cell Type	Species	Tissue
CRFK	epithelial	cat	kidney
HaK	epithelial	hamster	kidney
HEK293	fibroblast	human	embryonic kidney
A549	epithelial	human	lung carcinoma
Daudi	lymphoblast	human	blood from a lymphoma patient
H9	lymphoblast	human	T-cell lymphoma
HCT-15	epithelial	human	colorectal adenocarcinoma
HeLa	epithelial	human	cervix carcinoma
HL-60	lymphoblast	human	promyelocytic leukemia
HT-29	epithelial	human	colon adenocarcinoma
IM-9	lymphoblast	human	marrow from myeloma patient
JEG-2	epithelial	human	choriocarcinoma
Jurkat	lymphoblast	human	lymphoma
KB	epithelial	human	oral carcinoma
KG-1	myeloblast	human	marrow from erythroleukemia patient
MCF7	epithelial	human	breast adenocarcinoma
3T6	fibroblast	mouse	embryo
SIM-A9	fibroblast	mouse	connective tissue
BALB/3T3	fibroblast	mouse	embryo
I-10	epithelial	mouse	testicular tumor
Jensen	fibroblast	rat	sarcoma
LLC-WRC 256	epithelial	rat	carcinoma

Advantages of Our Service

Optimized gene editing platform.
Full-coverage centrosomal gene targets.

Flexible cell types and species.
Customized gene editing service.

Workflow of Our Service

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Our services are for research use only and not for any clinical use.