The cytoskeleton not only plays an important role in maintaining cell morphology and maintaining the internal structure of cells against external forces but is also involved in many important life activities. The physiological structure, function, and distribution of cytoskeletal proteins as well as their abnormal expression are closely related to the development of various diseases. With in-depth knowledge of cytoskeleton-related fields and extensive project experience, CD BioSciences provides reference materials on cytoskeleton and aging to help you understand our various assay services and welcomes you to contact us directly for more specific solutions.
Disease and Aging Affect Cytoskeletal Integrity
Aging is a complex feature involving loss of multiple functions and irreversible phenotypes, however, cytoskeletal integrity is closely associated with multiple functional activities of cells, such as senescence, proliferation, degeneration, and mitochondrial bioenergy production. Therefore, the regulation of cytoskeletal integrity may help to trigger anti-aging effects and treat degenerative diseases.
- Altered Actin Expression During Aging
Aging disrupts the organization and dynamics of the actin cytoskeleton by altering actin expression, leading to diseases associated with aging. Causes of altered actin expression include hormonal, nutritional and actin cytoskeleton polymerization activity states. At the same time, the actin cytoskeleton has an important role in cell division and apoptosis; therefore, actin dysfunction due to aging leads to uncontrolled cell proliferation and tumorigenesis.
Degeneration, aging, and inflammation associated with integrity of microtubules and dynamic movement of mitochondria [1].
- Alterations in Microtubule Regulation with Aging
Microtubule regulation is critical for neurons because their polarized morphology is maintained primarily by functioning microtubules. The numerous functions of neurons and the maintenance of neuronal structures require precise regulation of microtubule and actin dynamics, which can deteriorate with age and lead to neurodegenerative diseases, such as Parkinson's disease.
- Changes in Intermediate Filaments with Aging
An important function of intermediate filaments is to regulate the signaling that controls cell survival and growth. Intermediate filaments also contribute to the regulation of tissue repair and regeneration after injury. Waveform protein is an intermediate filament protein that is involved in regulating the function of endothelial cells and VSMC and contributes to arterial stiffness associated with aging.
Our Services
Cellular senescence is characterized by a reduced ability to adapt to environmental changes and a reduced ability to maintain a constant intracellular environment and is constitutionally characterized by a variety of degenerative changes that are associated with many diseases, including cancer. CD BioSciences has a variety of cellular research platforms that provide imaging and detection services for many types of aging cells.
- Mechanical Properties Analysis for Aging Cells
With our high-resolution microscope platform and rich experience in biomechanical research, we provide our clients with services to analyze the mechanical properties of aging cells.
- Cytoskeleton Imaging for Aging Cells
The integrity of the cytoskeleton is closely linked to a variety of functional activities of the cell, such as aging, proliferation, degeneration, and mitochondrial bioenergy production. With our high-resolution imaging technology, we provide cytoskeleton imaging services in aging cells to help our clients conduct studies of cytoskeletal senescence lesions.
Our Advantages
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CD BioSciences provides our global customers with cost effective, high quality and efficient research solutions for cytoskeleton related diseases. We guarantee on-time delivery of our products and results, please contact us for more details.
Reference
- Kim Y J, Cho M J, et al. Links of Cytoskeletal Integrity with Disease and Aging[J]. Cells, 2022, 11(18): 2896.
For research use only. Not intended for any clinical use.
