Cell mechanics is a frontier area of biomechanics and an important part of tissue engineering. with extensive experience in cell mechanics research, CD BioSciences builds cell mechanics models on demand to help clients study the mechanical properties of cells.
Common Cell Mechanics Models
Despite the different properties of the cytoskeleton and the types of networks they form, the polymers of the cytoskeleton are intricately linked together. These linked tissues and the resulting cytoskeletal network structures play a central role in transmitting compressive and tensile stresses and in sensing the mechanical microenvironment.
- Viscoelastic Gels of Cytoskeletal Polymers
The rheological similarities between some extracellular materials and synthetic polymer gels and the strong effect of actin depolymerizers on cellular mechanics have prompted attempts to explain cellular rheology using models developed for polymer networks.
- Colloidal, Glassy, and Foam Models for Cell Mechanics
Many aspects of the time dependence of cell rheology resemble the rheology of colloids, foams, or soft glassy materials, and recent systematic studies of cell elasticity and viscosity over much larger ranges of time and frequency than were previously possible have motivated researchers to challenge models of cell mechanics analogous to polymer gels.
Summary of the Three Types of Mechanical Models.
| Model Type |
Description |
Advantage |
Disadvantage |
| Schematic |
Schematic models are models that provide a one-dimensional relationship between stress, strain, and time. |
Easy to analyze and effective in detecting overall changes in mechanical properties. |
Limited ability to analyze specific structures. |
| Continuum Mechanics (CM) |
CM models assume that the materials being modeled are continuous, rather than discrete sets of particles, and that these models can be solved analytically or computationally. |
Fast and accurate setup of the system geometry, facilitating modeling for specific analyses. |
CM systems require a priori assumptions about the material properties of the system and cannot model discontinuous materials. |
| Molecular Dynamics (MD) |
In MD simulations, nuclei are discretized at the quasi-microscopic level, allowing researchers to specify the location and strength of bonds between nucleon structures. |
The system can easily analyze a wide range of materials with different interactions. |
A great deal of computational power and expertise is required to design an effective MD model, and some structural information is lost. |
The key to the study of cell mechanics is the mechanical loading of cells; therefore, the search for suitable cell loading methods and cell deformation and related biological measurement means is the primary problem of cell mechanics' research. According to the source of the simulated force, it is usually divided into two categories: simulation of in vivo mechanical environment and simulation of in vitro mechanical environment.
Our Services
Research has shown that both internal and external physical forces can act through the cytoskeleton to affect local mechanical properties and cellular behavior. CD BioSciences has a well-established technology platform and sophisticated instrumentation to accurately measure the mechanical properties of cells.
Cell Mechanics Model Construction
Cellular mechanics properties can be used as biological indicators to discriminate abnormal cells from normal ones, and cellular models are indispensable in the study of cellular mechanics. We have a well-developed cell manipulation process to provide our customers with various cell model construction services.
- Cell Schematic Model Construction
- Cellular Continuum Mechanics Model Construction
- Molecular Dynamics Model Construction
We have extensive experience in cell mechanics' research; we have been focusing on providing a high-quality biomechanical research platform and providing our customers with various cell mechanical properties testing services. For more information about our services, please feel free to contact us.
For research use only. Not intended for any clinical use.
