The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences uses cytoskeletal imaging, labeling and detection research tools and technical resources to save you more time for research and new discoveries. Design and optimize your protocols for high-quality experimental data using powerful assay kits and imaging systems.
Microtubule Dynamics
Microtubules are one of the four non-covalent polymers that make up the cytoskeleton, an integrated network of filamentous proteins that give cells their shape, facilitate their movement, organize their cytoplasm and construct the spindle needed to isolate genetic material. Microtubules are highly dynamic, oscillating randomly during growth and depolymerization, a property known as 'dynamic instability'.
The Tubulin Code Regulates Interactions with Microtubule Effectors [1].
Actin Dynamics
The actin cytoskeleton is a dynamic network that regulates cell behavior from development to disease. By rearranging the actin cytoskeleton, cells are able to migrate and invade during development. Actin filaments have two ends, spiny and pointed, with different polymerization properties. The polymerization kinetics of the barbed ends are much faster. Because polymerization is exothermic, it provides the energy required to propel cells through their environment or pathogens through the cell.
Overview of the structure and conformational dynamics of actin monomer and filament [2].
Intermediate filament Dynamics
The mechanical properties of vertebrate cells are largely defined by the intermediate filament system (IF). As part of a dense network, IF aggregates are constantly rearranged and repositioned within the cell to perform their duties as the cell changes shape, migrates or divides. IF networks in cells: a dynamic population of short filament squiggles and particles move at the cell periphery in order to be joined together and incorporate into the otherwise static network, and the network is broken down into squiggles and particles, which can move to a new location when the network needs to be reorganized.
Mechanisms of IF turnover [3].
Our Services
CD BioSciences provides the most comprehensive services for cytoskeleton dynamics imaging projects. Through strict monitoring and effective execution, we are committed to providing the best value solutions to complete your project.
- Microtubule Dynamic Imaging Services
One of the most striking properties of microtubules is their dynamic instability. Extensive phases of microtubule growth are followed by rapid disassembly and regrowth. We provide the most comprehensive services for microtubule dynamic imaging projects.
- Actin Dynamic Imaging Services
Dynamic actin networks play an important role in cell migration, morphogenesis, immune response and intracellular pathogen movement. We provide the most comprehensive services for actin dynamic imaging projects.
- Intermediate Filaments Dynamic Imaging Services
Intermediate fibers are closely related to microtubules and may have a role in microtubule assembly and stabilization. In addition, intermediate fibers extend from the nuclear fibril layer through the cytoplasm and have a supporting role for cellular rigidity and a coordinating role for structures that produce motility. We provide the most comprehensive services for intermediate fibers dynamic imaging projects.
Obtaining real-time information on cytoskeletal dynamics must ensure that the cells operate naturally during the experiment as much as possible in terms of physiological mechanisms, and therefore will make the experiment more difficult. CD BioSciences is committed to meeting our customers' research in the area of cytoskeletal dynamics by providing researchers with a choice of live cell imaging services through a variety of microscopy techniques.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
References
- Roll-Mecak A. The tubulin code in microtubule dynamics and information encoding[J]. Developmental cell, 2020, 54(1): 7-20.
- Hild G, Bugyi B, et al. Conformational dynamics of actin: effectors and implications for biological function[J]. Cytoskeleton, 2010, 67(10): 609-629.
- Robert A, et al. Intermediate filament dynamics: What we can see now and why it matters[J]. BioEssays, 2016, 38(3): 232-243.
For research use only. Not intended for any clinical use.
