The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences use prokaryotic cytoskeleton dynamic Imaging, labeling and detection research tools and technical resources to save you more time for research and new discoveries. Design and optimize your protocols for high-quality experimental data using powerful assay kits and imaging systems.
Cytoskeleton Dynamics in Prokaryotes
The idea of the cytoskeleton as a characteristic of eukaryotes was overturned when homologs of eukaryotic cytoskeletal elements were identified in prokaryotes and involved in major cellular functions including growth, morphogenesis, cell division, DNA distribution, and cell motility. FtsZ and MreB were the first identified homologs of microtubule and actin, respectively, followed by the discovery of crescentin as an intermediate filamentous protein.
- Cell division and FtsZ
Early in the cell cycle, FtsZ is rapidly redistributed from the poles throughout the cell. Prior to the subsequent division event as the chromosome is being replicated, the division site is selected by spatially regulated polymerization of FtsZ into a mid-cell ring. Depending on the organism, negative Z-ring regulators promote disassembly of FtsZ polymers near the poles, or positive Z-ring regulators promote local mid-cell assembly of FtsZ polymers. Z-ring assembly and condensation are further facilitated by association with membrane anchors and Z-binding proteins at mid-cell.
- Crescentin (CreS) and Eukaryotic IF Proteins
CreS has significant structural and biochemical correlation with eukaryotic IF proteins and was the first of this class to be identified; other proteins do not actually share a high degree of structural similarity with IF proteins and may actually exhibit convergent evolution, hence they are also known as coiled-coil-rich proteins, or Ccrps.
- Actin Homolog: MreB
Researchers have shown that MreB does not form large continuous structures as initially thought, but rather small discrete structures that move independently around the circumference of the cell along the cell membrane. Also, MreB movement is inhibited by certain antibiotics that disrupt cell wall cross-linking suggesting that MreB kinetics are closely linked to cell wall synthesis and are local coordinators of cell growth.
MreB localization depends on the local geometry of the cell surface [1].
Our Services
CD BioSciences provides the most comprehensive services for prokaryotic cytoskeleton dynamic imaging projects. Through strict monitoring and effective execution, we are committed to providing the best value solutions to complete your project.
In order to successfully perform live cell imaging experiments, it is critical to use the right platform. We offer a variety of live cell imaging systems to help our customers perform studies related to prokaryotic cytoskeleton more easily and quickly while protecting their samples.
- Dynamic Imaging for Microtubule Homologs
- Dynamic Imaging for Actin Homologs
- Dynamic Imaging for Intermediate Filament Homologs
Obtaining real-time information on prokaryotic cytoskeleton dynamics must ensure that the cells operate naturally during the experiment as much as possible in terms of physiological mechanisms, and therefore will make the experiment more difficult. Our high-performance imaging solutions can overcome these challenges of live cell imaging and help discover new information about cell physiology and dynamics.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
References
- Barrows J M, et al. FtsZ dynamics in bacterial division: What, how, and why? [J]. Current opinion in cell biology, 2021, 68: 163-172.
- Shi H, Bratton B P, et al. How to build a bacterial cell: MreB as the foreman of E. coli construction[J]. Cell, 2018, 172(6): 1294-1305.
For research use only. Not intended for any clinical use.
