Centrosome Detection & Quantification Services

Centrosome is a cell organelle that is consisted of a pair of centrioles and the pericentriolar material (PCM). The quantity, size, component and localization determine the functions of centrosome, and these factors vary from cell to cell. CD BioSciences provides centrosome detection & quantification service with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related disease.

Introduction into Centrosomes

Centrosome is a multi-functional cellular organelle that is consisted of a pair of centrioles and the pericentriolar material. The centrioles are composed of microtubules arranged in the form of the cylinder that grouped into nine sets of bundles of three microtubules each. Centrosome is involved in many biological processes, including the formation of spindles during mitosis, the anchorage of microtubules, the determination of cellular polarity chromosome segregation, transport of molecules across the cell, directional cell migration, and determination of cell shape. The structure, quantity, size and component of centrosomes are strictly controlled within cells. During the mitosis, centrosome duplicates once at the beginning of S phase, and recruits extra PCMs at G2 phase. At the end, two centrosomes are divided along with the cell division. The proper duplication, maturation and separation are fundamental for the bipolar spindles, which is the basis of faithful chromosome segregation.

The Link between Centrosomes and Human Disease

Centrosome Abnormalities (Wu Q, et al., 2020)

Centrosome abnormalities (CAs) are fairly universal among solid tumors and in many hematopoietic malignancies. Centrosome abnormalities include numeric abnormality and structural abnormality, including the centrosome amplification, centrosome loss, defects in centriole structure and defects in the amounts of PCM components. For example, the centrosome amplification is frequently observed in invasive breast cancers. In myeloid leukemia, non-Hodgkin's lymphoma and multiple myeloma, the centrosome numbers perform proliferative index with tumor grade. In some cancers, centrosome amplification results from centriole overduplication, such as the overexpression of centriolar proteins or PCM proteins. And in some other disease, such as ciliopathies and infertilities, centrosome structural defects are main reasons of the disorders.

The centrosome abnormalities have been proven to be potential target of therapeutic development of cancers and many other diseases. Due to the widespread distribution of centrosome abnormalities in human cancer, detection and quantification of centrosome abnormalities are very valuable in studies of centrosome-related diseases and the development of appropriate centrosome-targeting therapeutic targets.

Our Services

With the advanced technology, the cutting-edge equipment and rich experience in centrosome research, our professional scientists devote themselves to meet demands of our customers. For assisting our global customers making better progress in centrosome research, CD BioSciences offers centrosome detection & quantification services as follows.

Centrosome Isolation

Centrosome Quantification

Component Analysis

Structural Analysis

Centrosome Localization

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Wu Q, et al., Centrosome dysfunction: a link between senescence and tumor immunity. Signal Transduct Target Ther. 2020 Jun 30;5(1):107.

Our services are for research use only and not for any clinical use.