Centrosome Component Analysis Service

Centrosome abnormalities (CAs) are emerging hallmarks of malignant tumor. The numeric abnormality, known as centrosome amplification, has been reported in variety of cancers. CD BioSciences provides centrosome component analysis service with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related disease.

Overview of Centrosome Component

Centrosome is muti-functional membrane-less organelle, whose core is formed with a pair of nine-fold symmetrical cylindrical microtubule (MT)-based structures called centrioles. The second major part of the centrosome - the pericentriolar material (PCM) is organized by the centrioles. MTs are composed of a single type of globular protein called tubulin which is a dimer consisting of two closely related 55-kd polypeptides, α-tubulin and β-tubulin. The PCMs are highly structured and dense mass of protein that recruited gradually and hierarchically during centrosome formation and they are radially distribute from the centriole center.

PCM Proteins in Human Centrosome

The localization and abundance of mRNAs in PCM regulate its quantity and component, and many of them show unique distributions that correlate with cell cycle stage, and there is bias of these centrosomal mRNAs in different stages of mitosis.

In humans, defects in centriole structure, centrosome protein function or centrosome number cause mitotic and chromosome segregation errors, aneuploidy, cell cycle arrest, defects in cell polarity and tissue architecture, and negatively affect cilia formation and function.

Methods for Centrosome Component Analysis

By combining Raman micro-spectroscopy and algorithms for biomolecular component analysis, basic classes of biomolecules can be measured without cell destruction. In this technology, a source of laser light, usually from a laser in the visible, near infrared, or near ultraviolet range is used. And it interacts with molecular vibrations, phonons or other excitations in the system, giving information about the vibrational modes in the system. Therefore, macromolecular profiles of centrosome can be measured, which can be used as quantitative markers for centrosomal assessment.

Raman micro-spectroscopy of cells (Liendl L, et al., 2020)

Our Service

For assisting our global customers having better understanding of centrosome component and better progress in therapeutic development of centrosome-related disease, CD BioSciences provides centrosome component analysis services based on Raman micro-spectroscopy including but not limited as follows.

• Reveal differences in the biomolecular of centrosome between cell types.
• Reveal differences in the biomolecular of centrosome between stages of cell cycle.
• A novel quantitative marker for centrosomal assessment.

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Liendl L, et al., Raman fingerprints as promising markers of cellular senescence and aging. Geroscience. 2020 Apr;42(2):377-387.

Our services are for research use only and not for any clinical use.