Studies have shown that the phenotypic characteristics of various renal intrinsic cells can change according to physiological and pathological states. In renal disease states, different cells can undergo phenotypic transformation, and one of the characteristics of their transformation is the change of their cytoskeletal proteins. With in-depth knowledge of cytoskeleton-related fields and extensive project experience, CD BioSciences provides reference materials on cytoskeleton and chronic kidney disease to help you understand our various testing services and welcomes you to contact us directly for more specific solutions.
Clinical Manifestations of CKD
Chronic kidney disease (CKD) is usually identified by routine screening using serum chemistry profiles and urine studies or as an incidental finding. Less commonly, patients may present with symptoms such as hematuria of the naked eye, "foamy urine" (a sign of proteinuria), nocturia, back pain, or decreased urine output. If CKD progresses to an advanced stage, patients may report fatigue, loss of appetite, nausea, vomiting, metallic taste, unexpected weight loss, pruritus, altered mental status, dyspnea, or peripheral edema.
Definition and prognosis of CKD by GFR and albuminuria categories [1].
Cytoskeleton in CKD
On the molecular side, studies of heart failure in non-CKD populations have shown that alterations in the cytoskeleton are a major process in the pathogenesis of cardiomyopathy. The cytoskeleton of cardiomyocytes and cardiac fibroblasts consists of a complex network of microtubules, microfilaments, and intermediate filaments. Both cell types contain a rich network of cytoskeletal components that interact with other closely related proteomes and together maintain cellular morphological integrity, contractility, mechanical resistance, and transmit mechanical and chemical stimuli within and between cardiac cells.
Regulation of the cardiac cytoskeleton by FAK [1].
In patients with chronic kidney disease (CKD), there are several factors that cause cytoskeletal damage, including traditional risk factors (such as diabetes, hypertension, abnormal lipid metabolism, etc.) and non-traditional risk factors (such as proteinuria, inflammatory response, oxidative stress, etc.). Some of these factors can cause abnormal endothelial function by damaging the cytoskeletal structure, which in turn leads to the development of cardiovascular disease.
Our Services
Chronic kidney disease (CKD) is the 16th leading cause of life expectancy loss worldwide. Proper screening, diagnosis and management by primary care clinicians is necessary to prevent adverse outcomes associated with CKD. CD BioSciences provides the most comprehensive services for CKD disease programs. Through rigorous monitoring and effective execution, we are committed to providing the best value solution to complete your research project.
- Cytoskeleton Related Gene Mutation Detection in CKD
We help our clients to study the cytoskeleton changes in chronic kidney disease by analyzing DNA conformational or unstranding properties, or by performing DNA mutations using properties such as DNA denaturation and complexation.
- Inflammatory Response Detection
The expression and distribution of cytoskeletal proteins are affected in the inflammatory response caused by CKD. With our extensive biological research experience, we provide cytoskeletal protein expression assays in the inflammatory response to CKD as well as imaging services to help our clients delve into the pathological response to CKD and therapeutic development.
- Oxidative Stress Detection
With extensive biological research experience, we provide cytoskeletal protein expression assays in CKD oxidative stress as well as imaging services to help our clients delve into the pathological response and therapeutic development of CKD.
Features
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences provides our global customers with cost effective, high quality and efficient research solutions for cytoskeleton related diseases. We guarantee on-time delivery of our products and results, please contact us for more details.
References
- Chen T K, et al. Chronic kidney disease diagnosis and management: a review[J]. Jama, 2019, 322(13): 1294-1304.
- Halim A, et al. Myocardial Cytoskeletal Adaptations in Advanced Kidney Disease[J]. Journal of the American Heart Association, 2022, 11(5): e022991.
For research use only. Not intended for any clinical use.
