Metastasis is the cause of the largest number of cancer deaths. Metastatic disease, or the movement of cancer cells from one site to another, is a complex process that requires significant remodeling of the cytoskeleton. With in-depth knowledge of cytoskeleton-related fields and extensive project experience, CD BioSciences provides reference materials on cytoskeleton and tumors to help customers understand our related testing services and welcomes you to contact us directly for more specific solutions.
Cancer Cell Invasion and Metastasis
Metastasis is the process by which cancer migrates to distant organs and develops into metastatic lesions. However, cancer cells cannot accomplish this process alone. It is also known that the tumor microenvironment (TME) plays an important role in tumor metastasis. The mutual biochemical and biophysical interactions between tumor cells, stromal cells, and the extracellular matrix (ECM) result in a unique TME that determines the outcome of the disease.
To produce metastatic lesions, tumor cells must successfully complete all steps of the process.
- Detachment from Primary Tumor
- Cell Migration and Invasion
- Cell Death Induced by Cell Detachment
- Exocytosis
- Secondary Tumor Growth
Cytoskeleton in Cancer Metastasis
Metastasis is a complex process that requires significant reorganization of the cytoskeleton. Many proteins that interact directly or indirectly with the actin and microtubule cytoskeleton have been shown to significantly influence the migration and metastatic phenotype of tumor cells. New evidence on crosstalk between different components of the cytoskeleton in metastasis underscores the fact that the actin, IF, and MT cytoskeletons do not act in isolation but are inextricably linked in tumor cell migration and metastasis.
Typical protrusive structures in invasive cancer cells [1].
Our Services
Metastasis accounts for most cancer deaths and is the result of cancer cells moving from the primary site (the site of origin of the cancer) to a distant site or organ. CD BioSciences provides the most comprehensive testing and development services for tumor and cytoskeleton related research. Through rigorous monitoring and effective execution, we are committed to providing the most valuable solutions to complete your research project.
- Cancer Cell Biomechanical Assay Service
The biomechanical properties of cancer cells and their surrounding extracellular matrix have been proposed as promising biomarkers for cancer diagnosis and prognosis. CD BioSciences offers researchers a variety of cellular mechanics assays for cancer cells with its highly accurate cellular biomechanics analysis platform.
- Cytoskeleton-targeted Tumor Marker Development Service
We offer researchers biomarker testing for common cancers with its highly accurate cellular bioassay platform, and our comprehensive line of tumor markers and harmonized instruments provide laboratories with clinically meaningful results.
- Cytoskeleton-targeted Cancer Drug Development
One of the main characteristics of tumor cells is uncontrolled proliferation. In a multicellular organism, cell function and structure are closely related, so that functions related to cell growth are regulated, at least in part, by signals that can be transmitted by an organized cytoskeleton. CD BioSciences has many years of experience in providing anti-tumor screening services that target the cytoskeleton.
Our Advantages
Cost Effective
Customizable
High Quality
High Efficiency
CD BioSciences provides our global customers with cost effective, high quality and efficient research solutions for cytoskeleton related diseases. We guarantee on-time delivery of our products and results, please contact us for more details.
Reference
- Fife C M, et al. Movers and shakers: cell cytoskeleton in cancer metastasis[J]. British journal of pharmacology, 2014, 171(24): 5507-5523.
For research use only. Not intended for any clinical use.
