The cytoskeleton is the primary mechanical structure of the cell; it is a complex, dynamic network of biopolymers. with years of experience in cell biology research, CD BioSciences provides a platform for the analysis of the mechanical properties of cytoskeletal polymers to help our clients delve into the physiological mechanisms of the cytoskeletal polymer network.
Mechanical Properties of Cytoskeletal Networks
- Actin Filaments: During the spreading motion of these cytoskeletal substructures, the actin fibrils exhibited a distinctly nonlinear behavior. At the same time, the actin fibrils exhibited hyper elastic behavior during tension transmission when the tension applied was high.
- Microtubules: The sustained length of microtubules, a measure of filamentary flexibility that increases with stiffness, is so large that individual microtubules can form almost linear tracks and span the length of a typical animal cell.
- Intermediate Filaments: Intermediate filaments are the least stiff of the three cytoskeletal polymers, they resist tensile forces much better than they resist compressive forces, and many cell types assemble intermediate filaments in response to mechanical stress.
Cell Mechanics Measurement Technologies
- Atomic Force Microscopy
Among the various cell force measurement techniques, AFM has been the most used technique because it can characterize mechanical properties, including elasticity and viscoelasticity of many cell types.
- Traction Microscope
Another technique used to measure the forces exerted by cells on soft surfaces is 3D TFM, an important force measurement technique in which cells are cultured on a fluorescent microsphere bead-embedded ECM mimetic substrate in TFM experiments, and the traction forces generated by the cells are studied by measuring changes in bead displacement.
- Micropipette Aspiration
ln the technique of micropipette aspiration isolated nucleus mechanics can be studied by considering nucleus as relatively homogeneous material. In this technique the stressed sub nuclear structure can be visualized during deformation using various optical methods.
Our Services
Research has shown that both internal and external physical forces can act through the cytoskeleton to affect local mechanical properties and cellular behavior. CD BioSciences has a well-established technology platform and sophisticated instrumentation to accurately measure the mechanical properties of cells.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
For research use only. Not intended for any clinical use.
