Centrosome-related Disease Research Services

Centrosome is of great importance in massive biological processes, therefor the structure, function and number are strictly controlled within cells. The abnormalities of centrosome cause massive disorders, including cancers and ciliopathies. CD BioSciences provides centrosome-related services for diseases with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related disease.

Overview of Centrosome-related Diseases

Centrosome is of great importance in many biological processes, which promotes the production of bipolar mitotic spindles and supply a matrix of primary cilia in various cell types. The structure, function and number are strictly controlled within cells.

• The Relationships between Centrosome and Cancers

Centrosome abnormalities can lead to chromosomal instability, which can lead to aneuploidy, a state in which too many or too few chromosomes are present. Due to these features, centrosome abnormality is considered as biomarker of human cancers. Moreover, many centrosome-targeting compounds have been applied in cancer therapy successfully, such as paclitaxel and PARP inhibitors, and there are more of them under preclinical stage.

• The Relationship between Centrosome and Neurological Disease

Brain development is very sensitive to the aberrations in centrosome number and structure. Mutations in genes encoding proteins that regulate centrosome assembly and maturation causes many neurological diseases, such as microcephaly primary hereditary (MCPH), seckel syndrome (SCKL), and microcephalic osteodysplastic primordial dwarfism type II (MOPDII).

Representation of centrosome amplification pathways (Luan Y, et al. 2021)

• The Relationship between Centrosome and Infertility

Centrosome is of essential functions in sperm, such as forming the sperm tail during spermiogenesis, linking the sperm head and tail, mediating pronuclear migration. Therefore, centrosomal defects will cause fertilization failure and developmental arrest at the pronuclear stage. The absence of cilium is the main cause of male infertility.

• The Relationship between Centrosome and Ciliopathies

The mother centriole is able to transform into the basal body that is essential for cilium formation. The primary cilium serves as the sensory organ of cells, and it regulates a number of signaling pathways, such as Hedgehog, G-protein-coupled receptors, Wnt pathways and receptor tyrosine kineses. The absence or dysfunction of cilia results in a spectrum of disorders, namely ciliopathies, including reversal in body symmetry, retinal degeneration, and cystic kidney and liver diseases.

Our Services

Due to the deep relationship between centrosome and those diseases, launching studies of centrosome in disease is very valuable for their diagnostic and therapeutic development. With long-year experience in centrosome research and edge-cutting technologies, our scientists are willing to devote themselves for assisting you making breakthrough in the field of centrosome research. CD BioSciences offers centrosome-related services for diseases including but not limited as follows.

The services we provide are including but not limited as follows.

Cancer

Neurological Diseases

Infertility

Ciliopathies

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Luan Y, et al. Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors? Biomed Pharmacother. 2021 Dec;144:112292.

Our services are for research use only and not for any clinical use.