Centrosome-related Service for Cancers

Centrosome is the major microtubule organizing centers (MTOCs) in most cells, which in highly involved in regulating cell cycle. Cancers are diseases involving abnormal cell growth with the potential to spread to other parts of body. Centrosome abnormality is considered as one of the cause for cancers. CD BioSciences provides centrosome-related services with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related cancers.

Relevance between Centrosome and Cancers

Centrosome is the major microtubule organizing center (MTOC) of animal cells, which consists of a pair of barrel-shaped centrioles surrounded by PCM. Centrosomes serve as coordination centers in eukaryotic cells and orchestrate signal transduction, cell division, polarity and migration. The centrosome duplication is spatially and temporally synchronized with DNA duplication, and any defect or disturbance during the duplication and elongation/maturation stages results in centrosomal abnormalities. The aberrations in number, structure, position and shape of centrosome are collectively known as centrosome abnormalities, which are highly correlated with malignant tumor.

Normal and cancer cell with extra centrosomes during cell cycle (Mittal K, et al., 2021)

Once the cell is in the mitotic phase, specifically at prophase, the two centrosomes migrate to the opposite poles of the cell and the mitotic spindle forms between centrosomes, facilitating cell division. Numeric amplification of centrosomes results from abnormal centriole biogenesis due to centriole overduplication and de novo assembly, or mitotic/cytokinetic failure or fusion which passively increase the centrosome copy number in a sub-population of progeny cells. It's frequently observed in anogenital cancers, aggressive breast cancers.

Our Services

For assisting our global customer making better progress in centrosome-targeted therapeutic development, and exploring the relevance between centrosome abnormalities and cancers for detecting in early stage, CD BioSciences offers centrosome-related services in cancers including but not limited as follows.

Breast Cancer

Ovarian Cancer

Colon Cancer

Lung Cancer

Liver Cancer

Kidney Cancer

Gastric Cancer

Brain Cancer

Blood Cancer

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Mittal K, et al. Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies. Cancer Metastasis Rev. 2021 Mar;40(1):319-339.

Our services are for research use only and not for any clinical use.