Centrosome-related Service for Neurological Disease
InquiryBrain development is very sensitive to the number, structure and function of centrosome. The mutations of many centrosomal genes have been identified in some neurological diseases. And the centrosomal proteins are localized in specific subtypes of neural stem cells, regulating neurogenesis via microtubule organization. CD BioSciences provides centrosome-related service with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related neurological diseases.
Centrosome Research in Neurology
Centrosomes plays important role in most microtubule related processes, such as motility, cell division and cell signaling. For coordinating these diverse cellular processes, the number of centrosomes must be tightly controlled. Brain development is very sensitive to the number, structure and component of centrosome. Typical neurological disease revelated with centrosome abnormalities are as follows:
- Seckel syndrome (SCKL)
- Microcephaly primary hereditary (MCPH)
- Microcephalic osteodysplastic primordial dwarfism type II (MOPDII)
Newborns affected by these diseases manifest reduced cerebral cortex size and intellectual disability, although the overall organization of the brain is usually unaffected. During cell cycle, the centrosome numeric abnormality causes a mitotic delay and chromosome missegregation. What's more, the centrosomes regulate assembling of primary cilium, which plays important role in cell migration and signal transmission. Therefore, the centrosome abnormalities cause causing abnormal signaling and premature neural differentiation.
Centrosomal Genes and Related Neurological Diseases
| Gene | Diseases and Clinical Features |
|---|---|
| ASPM | microcephaly, mild to severe cognitive impairment, seizures and short stature |
| CDK5RAP2 | microcephaly and short stature |
| CEP63 | microcephaly and short stature |
| CEP135 | microcephaly |
| CEP152 | microcephaly, moderate cognitive impairment and simplified gyri |
| proportionate short stature, severe microcephaly, mental retardation and simplified gyri | |
| CPAP/CENPJ | microcephaly, mild to severe cognitive impairment and facial dysmorphism |
| Proportionate short stature, microcephaly, skeletal anomalies | |
| MCPH1 | microcephaly, short stature, premature chromosome condensation and mild to severe cognitive impairment |
| ORC1 | proportionate short stature, microcephaly, knee and ear abnormalities and skeletal abnormalities |
| PCNT | extreme but proportionate short stature, bone abnormalities, microcephaly and near normal intelligence |
| STIL | microcephaly, ataxia and short stature |
| WDR62 | microcephaly, pachygyria, hypoplesia of corpus callosum, cortical thickening, lissencephaly, polymicrogyria and facial dysmorphism |
Our Services
Brain development is extremely sensitive to the number, structure and function of centrosome. The centrosome abnormality effects the asymmetric cell division of neural stem cell, in which condition that the patients have many disorders during brain development. For assisting our global customers making better progress in centrosome-targeting diagnostic and therapeutic development of neurodevelopmental disorder. CD BioSciences offers centrosome-related services including but not limited as follows.
Pathologic Research of Neurological Diseases
- Identification of Pathogenic Centrosomal Genes
- Identification of Centrosome Involved Pathways
- Detection of Centrosome in Neurological Diseases
Therapeutics Development of Neurological Diseases
Why Choose Us
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With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.
Our services are for research use only and not for any clinical use.
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