Centrosome-related Detection Service for Infertility

The functions of centrosomes in sperm include orchestrating early spermatogenic cell divisions, forming the spermatozoon flagella, linking the spermatozoon head and tail, controlling sperm tail beating, and organizing the cytoskeleton of the zygote post-fertilization. The centrosome abnormalities cause infertilities. CD BioSciences provides centrosome-related detection service in gametes with our advanced technology and experienced experts for meeting our global customer's demands in centrosome research and the therapeutic development of centrosome-related disease.

Introduction into Centrosomes in Germ Cells

Centrosomes are eukaryotic subcellular structures that produce and regulate massive subcellular cytoskeleton superstructures, they are formed with a pair of centrioles and the cilia are formed from them. Sperm centrosomes exhibit many unique characteristics not commonly observed in other cell types, including structural remodeling, centriole-flagellum transition zone migration, and cell membrane association during meiosis.

Behaviors of Centrosome during Fertilization

• In sperm cells: The mature human sperm contains a centrosome which consists of the proximal centriole and the distal centriole. During the process of spermiogenesis, the centrioles and their surrounding PCM are remodeled through centrosome reduction. The proximal centriole is introduced into the oocyte, contributing to sperm aster formation, which is very important for uniting sperm and oocyte pronuclei. And the distal centrosome and its surrounding PCMs serve as dynamic basal complex.
• In oocytes: The centrosomes are originally contained in the oogonia, and they are eliminated during oogenesis. However, PCM and some centrosome-related proteins, such as PCNT, γ-tubulin, and nuclear mitotic apparatus are retained.

Centriole Remodeling During Spermiogenesis (Avidor-Reiss T, et al., 2022)

The basic functions of centrosome during spermiogenesis include forming the sperm tail, linking the sperm head and tail, mediating pronuclear migration. Due to these key functions, centrosome abnormalities in sperm result in a spectrum of disease, such as oligozoospermia, asthenozoospermia, teratozoospermia, and acephalic spermatozoa syndrome. What's more, the centrosomes in sperm are infected by many other factors, such as aging, pathogens, health conditions, cryopreservation, and environmental factors. Therefore, evaluation of centrosome structure, component, quantity and function are valuable for the fertilization.

Our Services

The abnormality of centrosome is the main cause of male infertility, due to its important role as the basal body that organizing flagella, the motile cilia enable sperms cells swimming through liquid. Therefore, centrosome is considered as a promising target for infertility therapy. For assisting our global customer making better progress on centrosome-targeting diagnostic and therapeutic development of infertility, CD BioSciences offers centrosome-related detection services including but not limited as follows.

Why Choose Us

Professional Team

Comprehensive Platform

High Efficiency

One-stop Service

With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.

Reference

1. Avidor-Reiss T, et al., The sperm centrioles. Mol Cell Endocrinol. 2020 Dec 1;518:110987.

Our services are for research use only and not for any clinical use.