The proteins that make up the microtubules of tubulin are called microtubule, and it plays an essential role in maintaining cell shape, motility, and intracellular material transport. CD BioSciences saves you more research time and new discoveries with one-stop protein purification services through a wealth of protein expression systems and technical resources. Design and optimize your protocols with powerful assay kits and imaging systems to obtain high-quality experimental data.
Overview of Microtubule
Microtubule is a globulin, the basic structural unit of intracellular microtubules. It is a heterodimer formed by the polymerization of two protein molecules, ie. α- and β-tubulin molecules; each such dimer is combined with two nucleotide molecules, one is tightly bound and the other is loosely bound, and can be exchanged rapidly. As an important part of the cytoskeleton, microtubule is involved in chromosome movement, mitosis and apoptosis. Studies have shown that many diseases are associated with changes in microtubule, and whenever cellular DNA is altered and mitosis is affected, changes in microtubule can be manifested.
Representative DyMIN images of procentrioles stained for α-tubulin [1].
Different Types of Microtubule Proteins
| Microtubule Associated Proteins |
Function |
| Stathmin |
Depolymerization |
| XMPA215 |
Polymerization factor |
| EB |
Polymerization, Stabilization, Recruitment of proteins |
| DCX |
Polymerization factor, Stabilization |
| CLASP |
Stabilization |
| APC |
Stabilization |
| mDia1 |
Stabilization |
| mDia2 |
Stabilization |
| Tau |
Stabilization |
| Microtubule Associated Proteins |
Function |
| MAP2 |
Stabilization |
| Spastin |
Microtubule severing |
| Katanin |
Microtubule severing |
| Kinesin |
Cargo transport |
| Dynein |
Cargo transport |
| MACF1 |
Actin-Microtubule interactions |
| Cdc42 |
Signaling molecule, activates PAK |
| Rac1 |
Signaling molecule, activates PAK |
| RhoA |
Signaling molecule, mDia1 |
Our Services
CD BioSciences provides the most comprehensive services for microtubule proteins purification. We can provide label-free purified proteins for structural analysis, natural protein purification, soluble proteins at the gram or kilogram level and beyond. Through strict monitoring and effective execution, we are committed to providing the most valuable solution to complete your project.
The common protein tags we provide are 6xHIS, Flag, GST, c-Myc, eGFP/eCFP/eYFP/mCherry, HA, SUMO, etc.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Gambarotto, Davide, et al. "Imaging cellular ultrastructures using expansion microscopy (U-ExM)." Nature methods 16.1 (2019): 71-74.
For research use only. Not intended for any clinical use.
