Microfilaments are formed by the helical polymerization of actin molecules, also known as actin filaments, which together with microtubules and intermediate fibers form the cytoskeleton and are a highly conserved protein. Microfilaments are important for many cellular functions such as cell attachment, spreading, motility, endocytosis, and cell division. CD BioSciences saves you more research time and new discoveries with one-stop protein purification services through a wealth of protein expression systems and technical resources. Design and optimize your protocols with powerful assay kits and imaging systems to obtain high-quality experimental data.
Overview of Actin
Microfilaments are double-stranded actin filaments in the form of a helix. Microfilaments, together with its binding protein and myosin, form a chemo mechanical system that uses chemical energy to generate mechanical motion. Vertebrate actin is divided into three types: α, β and γ. Polymeric and non-polymeric actin can interact with a variety of binding proteins that regulate actin polymerization and the stability, length and distribution of microfilaments.
Components of the actin cytoskeleton in migrating cells [1].
Different types of Actin Proteins
| Actin Associated Proteins |
| Arp2/3 |
Ena/VASP |
Arp2/3 |
mDia1 |
| mDia2 |
Profilin |
ADF/Cofilin |
Arpin |
| Myosin II |
RLC |
MLCK |
MHCK |
| PKC |
CKII |
CKII |
CKII |
| α-actinin |
Filamin |
N-WASP |
WASP/WAVE |
| MAP2 |
Spastin |
Katanin |
Kinesin |
| Dynein |
MACF1 |
Cdc42 |
Rac1 |
| RhoA |
Fimbrin |
Paladin |
Ezrin |
| Radixin |
Moesin |
ROCK |
|
Our Services
CD BioSciences provides the most comprehensive services for actin purification. We can provide label-free purified proteins for structural analysis, natural protein purification, soluble proteins at the gram or kilogram level and beyond. Through strict monitoring and effective execution, we are committed to providing the most valuable solution to complete your project.
The common protein tags we provide are 6xHIS, Flag, GST, c-Myc, eGFP/eCFP/eYFP/mCherry, HA, SUMO, etc.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Svitkina, Tatyana. "The actin cytoskeleton and actin-based motility." Cold Spring Harbor perspectives in biology 10.1 (2018): a018267.
For research use only. Not intended for any clinical use.
