The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences use neurofilament structure imaging, labeling and detection research tools and technical resources to save you more time for research and new discoveries. Design and optimize your protocols for high-quality experimental data using powerful assay kits and imaging systems.
The Structure of Neurofilaments
Neurofilaments are large numbers of fibrous structures with an approximate outer diameter of 10 nm contained in neurons, which act as a cytoskeleton to maintain neuronal morphology. The neurofilaments (NFs) are unique among the class of tissue-specific intermediate filaments (IFs) in that they are composed of four subunits, NF-L (light neurofilaments); NF-M (medium neurofilaments); NF-H (heavy neurofilaments) and alpha-internexin or peripherin, each with a different structural domain and function.
Domain structure and posttranslational modifications of neurofilament (NF) subunits [1].
NF Domain Structure
- NF-Ls: Within the NF bundle, human NF-Ls are extremely stable filamentous structures with half-lives in the order of ~ 21 to ~ 55 days or longer，and can be used as a biomarker and indicator of neuropathology.
- NF-M: NF-M has a long carboxy-terminal structural domain and multiple highly phosphorylated lysine-serine-proline (KSP) overlap sequences. The phosphorylation and O-linked glycosylation sites on the NF subunit are shown.
- NF-H: The NF-H protein sequence contains an unusual tandem repeat of 6-8 amino acid sequences centered on a lysine-serine-proline (KSP) sequence.
Our Services
CD BioSciences offers services including real-time neurofilaments localization, 3D structural imaging, and crystal structure analysis by combining powerful automated image acquisition and analysis with the help of our versatile microscopic instruments. Our microscopy systems provide you with intelligent innovations in structural imaging that can help you achieve optimal image quality.
- Multiple High Quality Structural Imaging Systems
- Neurofilaments Structural Imaging During Neuronal Migration
- Neurofilaments Structural Imaging for Different Species
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Yuan A, Rao M V, et al. Neurofilaments and neurofilament proteins in health and disease[J]. Cold Spring Harbor perspectives in biology, 2017, 9(4): a018309.
For research use only. Not intended for any clinical use.
