The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences use microtubule dynamic imaging, labeling and detection research tools and technical resources to save you more time for research and new discoveries. Design and optimize your protocols for high-quality experimental data using powerful assay kits and imaging systems.
Microtubule Polarity
Different cellular functions, such as cell division, migration, tissue formation, secretion, and signaling, are associated with the generation of cellular asymmetry. Microtubule networks are involved in these processes by responding to and promoting cell polarity. Microtubules themselves are inherently polarized because they have two distinct ends, the negative end and the positive end. The negative end exhibits slow dynamics and can be stably anchored in the center of various microtubule tissues, while the positive end can grow and contract rapidly and interact with different intracellular structures.
Polarization Regulation of Microtubule Density and Stability
Various proteins can interact with polymerized microtubule ends to stabilize or disrupt them or to direct their direction of growth. The major players in this regulation are microtubule plus end tracking proteins (+TIP) and their partners, which can control microtubule dynamics and attach microtubules to the cell cortex or actin cytoskeleton. At the same time, microtubules are involved in various regulatory pathways that amplify deviations in the organization of microtubule networks, control actin contractility, and promote cell polarity.
Microtubule regulation in the vicinity of focal adhesions [1].
Our Services
CD BioSciences provides the most comprehensive services for microtubule polarity research. Through strict monitoring and effective execution, we are committed to providing the best value solutions to complete your project.
- Dynamic Imaging of Chromosome Segregation
Polar microtubules and motor proteins are involved in the segregation of chromosomes in mitosis.
- Cell Polarity Imaging
The formation of cell polarity is mediated by the cytoskeleton, which reorganizes the cytoskeletal system in response to stimulation by non-polar inducing sources and leads to an asymmetric distribution of the molecular components.
- Polarized Cell Migration Dynamics Imaging
The most striking feature of migrating cells is the polarization of the cells along the anterior-posterior axis in the moving plane, especially when the cells crawl in a two-dimensional plane, and it is easy to distinguish their anterior and posterior ends.
Obtaining real-time information on microtubule polarity dynamics must ensure that the cells operate naturally during the experiment as much as possible in terms of physiological mechanisms, and therefore will make the experiment more difficult. Our high-performance imaging solutions can overcome these challenges of live cell imaging and help discover new information about cell physiology and dynamics.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Meiring J C M, et al. Generation and regulation of microtubule network asymmetry to drive cell polarity[J]. Current Opinion in Cell Biology, 2020, 62: 86-95.
For research use only. Not intended for any clinical use.
