Cat. No. CIA-11327
CAS No. 76343-93-6
Key Features and Details
Product Size
Online Inquiry| Product Overview | |
|---|---|
| Activity | Actin polymerization inhibitor |
| Description | Actin polymerization inhibitor. Potent antiproliferative agent. |
| Product Details | |
|---|---|
| Product Name | Latrunculin A (LAT-A) |
| Chemical Name | (4R)-4-[(1R, 4Z, 8E, 10Z, 12S, 15R, 17R)-17-Hydroxy-5, 12-dimethyl-3-oxo-2, 16-dioxabicyclo[13.3.1]nonadeca-4, 8, 10-trien-17-yl]-2-thiazolidinone |
| PubChem ID | 445420 |
| CAS. No. | 76343-93-6 |
| Molecular Formula | C22H31NO5S |
| Biological Description | Actin polymerization inhibitor. Potent antiproliferative agent. Stabilizes monomeric G-actin. Shows greater potency than Latrunculin B. Binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry. Inhibits growth of cancer cell lines (IC50 values are 142, 142, 142, 166 and 95 nM for A549, H522-T1, HT-29, U-937 and MDA-MB-43 cells respectively). Shows convulsant effects in vivo. |
| Solubility | Soluble in ethanol to 10 mM and in DMSO to 10 mM |
| Purity | >95% |
| Molecular Weight | 421.55 |
| SMILES | C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C |
| Source | Cacospongia mycofijiensis |
| Storage & Handling | |
|---|---|
| Storage Instructions | Store at -20 °C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. |
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
For research use only. Not intended for any clinical use.