Microtubules have dynamic characteristics of polymerization and depolymerization. They polymerize to form spindles in the prophase of cell division and depolymerize to tubulin in the anaphase of cell division. They play an important role in maintaining cell morphology, cell division, signal transduction and material transport. CD BioSciences provides a large number of compounds for microtubule research. We actively follow the latest science, so our customers can rely on us to provide the latest types of microtubule inhibitors and activators.
Microtubule Associated Compounds and Their Therapeutic Applications
Microtubules play an extremely important role in cell division. Destruction of mitotic spindle formation will affect all dividing cells. For cancer cells that proliferate faster than most normal cells, anti-mitotic drugs can preferentially kill cancer cells when used in anti-tumor therapy. The development and application of such drugs is also an important part of the history of human anticancer drugs.
Effects of microtubule stabilizers on the cellular interphase microtubule network of A-10 cells [1].
Screening antitumor drugs by using microtubules as targets is one of the effective ways to develop new antitumor drugs. Mitotic catastrophe is a new way to induce cell death and is one of the mechanisms of antitumor action of some microtubule inhibitors such as paclitaxel and colchicine.
| Category |
Structural Domain |
Generic Name |
Indication |
| Polymerization Inhibitors |
Vinca Domain |
Vincablastine |
Breast cancer, head and neck cancer, Hodgkin's lymphoma, leukemia, etc. |
| Colchicine Domains |
Colchicine |
Non-neoplastic diseases, gout, etc. |
| Paclitaxel Domain |
Paclitaxel Domain |
Paclitaxel |
Head / neck cancer, lung cancer, breast cancer, ovarian cancer, etc. |
| Huddle Dynamics Inhibitors |
Paclitaxel Domain |
Eribulin |
Breast cancer, liposarcoma, etc. |
Our Services
The development of new microtubule inhibitors that induce mitotic catastrophe in tumor cells has become an important area of future antitumor drug research. CD BioSciences offers screening services for microtubule targeting agents with a vast library of compounds that can be used for microtubule-related mechanistic studies and drug development.
Customizable Compound Library for Microtubules
To ensure that you find the right microtubule compound for your study and guarantee the success of your research, customers can select compounds from our inventory to build a library of compounds suitable for your research.
Compound Screening for Microtubules
- Inhibitor or Activator Screening for Microtubules
- Inhibitor or Activator Screening for Prokaryotic Homologues of Microtubules
Drug Toxicity Detection
New compounds may cause toxic damage to various tissues and organs, and these toxicities can be detected early in the corresponding cellular models, providing important reference information for drug development. With years of experience, we are able to provide our clients with toxicity detection services for various compounds.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Rohena C, et al. Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities[J]. Natural product reports, 2014, 31(3): 335-355.
For research use only. Not intended for any clinical use.
