The primary function of intermediate filaments is to produce cellular cohesion and prevent acute rupture of epithelial cell sheets under tension to help utilize and protect cellular DNA. CD BioSciences offers a wide range of compounds for intermediate filament research. We actively follow the latest science, so our customers can rely on us to provide the latest types of intermediate filament protein inhibitors and activators.
Intermediate filaments are closely related to microtubules and may have a role in microtubule assembly and stabilization. Not only do they support cellular rigidity and coordinate structures that produce motility, but more importantly, intermediate fibers are associated with important life processes such as cell differentiation, intracellular messaging, intranuclear gene transfer, and intranuclear gene expression. The most common intermediate filament proteins are neurofilament proteins, vimentin and keratin.
| Name | Target | Description |
|---|---|---|
| Withaferin A | vimentin | Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. |
| Triolein | keratin | Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes. |
| Tapinarof | AhR | Tapinarof is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT). |
Intermediate filaments are associated with cell differentiation, intracellular messaging, intranuclear gene delivery, intranuclear gene expression, and other vital life processes. CD BioSciences provides screening services for intermediate filament protein-targeted drugs and has a large library of compounds for intermediate filament protein-related mechanistic studies and drug development.
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CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
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