The dynamic properties of actin polymerization and depolymerization are extremely important for functions such as cell adhesion and migration, and they play an important role in maintaining muscle tissue, cell migration, etc. CD BioSciences offers a wide range of compounds for microtubule research. We actively follow the latest science, so our customers can rely on us to provide the latest types of microtubule protein inhibitors and activators.
Actin Binding Compounds and Their Therapeutic Applications
A large number of diseases and disorders are caused by mutations in the alleles of genes that regulate the production of actin or its related proteins. Actin production is also key to the infection process of some disease-causing microorganisms. Mutations in different genes that regulate the production of human actin can cause muscle disease, changes in heart size and function, and deafness. The composition of the cytoskeleton has also been linked to the pathogenicity of intracellular bacteria and viruses, particularly in processes related to evasion of the action of the immune system.
Catabolism of Actin [1].
Actin forms filaments, which are essential components of the eukaryotic cytoskeleton and are capable of undergoing very rapid polymerization and depolymerization kinetics. In most cells, actin filaments form larger networks, which are essential for many critical functions in the cell. There are many toxins that can interfere with actin dynamics by preventing actin polymerization, such as latrunculin and cytochalasin D; or by stabilizing actin, such as Phalloidin.
Common Actin Targeting Agents
| Name |
Target |
Description |
| Latrunculin |
G-actin |
Latrunculin is a toxin produced by sponges and prevents it from binding to microfilaments. |
| Cytochalasin D |
F-actin |
Cytochalasin D has been found to disrupt the dynamics of actin and activate the protein p53 in animals. |
| Phalloidin |
F-actin |
Phalloidin is a toxin isolated from the dead mushroom Amanita phalloides. It binds to the interface between adjacent actin monomers in F-actin polymers and prevents their depolymerization. |
Our Services
Actin is involved in many important cellular processes, including muscle contraction, cell motility, cell division and cytoplasmic division, vesicle and organelle motility, cell signaling, and the establishment and maintenance of cell junctions and cell shape. CD BioSciences provides screening services for actin-targeted drugs and has a large library of compounds for actin-related mechanistic studies and drug development.
- Customizable Compound Library for Actin
To ensure that you find the right actin compound for your study and guarantee the success of your research, customers can select compounds from our inventory to build a library of compounds suitable for your research.
- Compound Screening for Actin
- Inhibitor or Activator Screening for Actin
- Inhibitor or Activator Screening for Prokaryotic Homologues of Actin
- Drug Toxicity Detection
New actin-related compounds may cause toxic damage to a variety of tissues and organs, and these toxicities can be detected early in the corresponding cellular models. With many years of experience, we are able to provide our clients with toxicity testing services for a variety of actin-related compounds, providing important reference information for subsequent drug development.
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Hung R J, et al. Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL‐mediated actin filament disassembly[J]. Cytoskeleton, 2011, 68(8): 415-433.
For research use only. Not intended for any clinical use.
