The cytoskeleton not only plays an important role in maintaining cellular morphology and maintaining the internal structure of the cell to withstand external forces, but also participates in many important life activities. The physiological structure, function and distribution of cytoskeletal proteins and their abnormal expression are closely related to the development of neurological and renal diseases. With in-depth knowledge of cytoskeleton-related fields and extensive project experience, CD BioSciences provides reference materials on cytoskeletal diseases to help you learn more about our various testing services and welcome you to contact us directly for more specific solutions.
Cytoskeletal Proteins in Neurological Diseases
The cytoskeleton, an organelle formed by a three-dimensional scaffold of proteins, is particularly important in defining the physiological properties of neurons. Due to the development and entire existence of the nervous system, the cytoskeleton is essential for maintaining neuronal function.
Neurons are morphologically different from other cells because they have compartmentalized structures: dendrites, neuronal cytosol, axons, and axon terminals. In each compartment, cytoskeletal proteins have specific functions, with the goal of ensuring the transmission of electrical and chemical signals between neurons. Given the importance of the cytoskeleton for neurons, several neurological disorders either involve changes in the expression, dynamics and stability of cytoskeletal proteins or are the result of mutations in them.
Main elements of the neuronal cytoskeleton [1].
Neurological Disorders Caused by Cytoskeletal Lesions
The cytoskeleton is an extremely complex organelle. This complexity is easy to understand. Neurons are rather peculiar cells with extremely long processes that play roles of paramount importance. Axons are very dynamic structures, a property which is reflected in the fact that they can even regenerate in some circumstances. This capacity is largely dependent on cytoskeleton structure and dynamics, which grant the versatility of the growth cone responding to its environment. Since cytoskeletal proteins and regulators also perform other critical roles in neuronal function (axonal transport, neurotransmitter secretion, etc.), they have become increasingly involved in devastating diseases, most of them without actual treatment.
| Disease |
Protein |
Description |
| Friedreich's Ataxia |
Frataxin |
GAA-triplet repeats expansion or point mutations in the FXN gene. |
| Sporadic Alzheimer Disease |
N/A * |
Sporadic Alzheimer disease (SAD) has a variety of initiating factors. |
| Familial Alzheimer Disease |
Amyloid B-protein/APP; Presenilin-1/PSEN1; Presenilin-2 /PSEN2 |
Familial Alzheimer Disease (fAD) is a genetically heterogeneous disorder. |
| Sporadic Parkinson Disease |
N/A * |
Sporadic Parkinson Disease (SAD) has a variety of initiating factors. |
| Familial Parkinson Disease |
27 causative genes associated with PD |
Familial Parkinson Disease (fAD) is a genetically heterogeneous disorder. |
| Huntington's Disease |
Huntingtin /HTT |
Expansion of CAG repeats in the HTT gene |
Our Services
Based on extensive experience in companion diagnostic development, high-quality management systems and a highly qualified R&D management team, CD BioSciences offers a variety of improved in vitro models of neurodegenerative diseases that, combined with advanced cellular models, may deepen our understanding of the mechanisms of action of neurodegenerative diseases and contribute to relevant drug discovery.
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CD BioSciences provides our global customers with cost effective, high quality and efficient research solutions for cytoskeleton related diseases. We guarantee on-time delivery of our products and results, please contact us for more details.
Reference
- Muñoz-Lasso D C, et al. Much more than a scaffold: cytoskeletal proteins in neurological disorders[J]. Cells, 2020, 9(2): 358.
For research use only. Not intended for any clinical use.
