The cytoskeleton of animal cells is one of the most complex and functionally diverse structures involved in processes such as endocytosis, cell division, intracellular transport, motility, force transmission, response to external forces, adhesion and preservation, and cell shape adaptation. These functions are mediated by three classical cytoskeletons. CD BioSciences, with its in-depth research in the field of cell biology, offers our clients a wide range of services for the analysis of cytoskeletal functions.
Function of Cytoskeletal Proteins
The cytoskeleton is a large structure within the cell that provides mechanical support for cells, maintains their three-dimensional shape and internal structure, and performs various physiological functions that allow them to move and divide.
Functions of Actin
In most cells, actin filaments form larger networks, which are essential for many critical functions in the cell.
- Providing mechanical support to the cell and providing transport pathways through the cytoplasm to aid signal transduction.
- Rapid assembly and disassembly of the actin network leading to cell migration.
- Act as a scaffold for myosin-generated forces to support muscle contraction.
The Arp2/3 complex [1].
Functions of Microtubule
Microtubule structure [2].
Microtubules are mainly found in the cytoplasm and are distributed in a reticular or bundle-like pattern. To adapt to the changes of cytoplasm, it can assemble and de-assemble quickly, showing dynamic structural characteristics.
Microtubules have important biological functions, such as maintaining cellular morphological structure, participating in cell motility, intracellular material transport, signal transduction, and cell division.
Functions of Intermediate Filaments
Intermediate filaments are the third skeletal component of the cell and are called intermediate filaments because their average diameter is between microtubules and microfilaments.
Intermediate filaments are closely related to microtubules and are involved in important life processes such as cell differentiation, intracellular information transfer, intranuclear gene transfer, and intranuclear gene expression.
Intermediate filament’s structure [3].
Our Services
Cytoskeleton is a network of protein fibers in eukaryotic cells that plays an important role in various cellular physiological processes. CD BioSciences is known for its cytoskeleton-related research and provides functional analysis of various types of cytoskeletons for our clients.
- Cytoskeletal Component Separation
One of the important research tools for the study of cytoskeleton structure and function is the separation of pure subcellular components. CD BioSciences provides services for the separation of cytoskeleton components so that various biological processes in the cell are separated from each other and do not interfere with each other, facilitating the determination of the details of a complex process and helping clients deepen their understanding of the overall function of the cytoskeleton.
- Cytoskeletal Protein Functional Assay
- Microtubule Functional Analysis
- Actin Functional Analysis
- Intermediate Filaments Functional Analysis
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
References
- Pollard T D. Actin and actin-binding proteins[J]. Cold Spring Harbor perspectives in biology, 2016, 8(8): a018226.
- Goodson H V, et al. Microtubules and microtubule-associated proteins[J]. Cold Spring Harbor perspectives in biology, 2018, 10(6): a022608.
- Goldman R D, et al. Inroads into the structure and function of intermediate filament networks[J]. Journal of structural biology, 2012, 177(1): 14-23.
For research use only. Not intended for any clinical use.
