The cytoskeleton controls the morphological and dynamic character rustics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences use amyloid fibril's structure imaging, labeling and detection research tools and technical resources to save you more time for research and new discoveries. Design and optimize your protocols for high-quality experimental data using powerful assay kits and imaging systems.
The Structure of Amyloid Fibrils
Amyloid fibrils are self-assembled, filamentous protein or peptide aggregates with cross-β molecular structures, meaning that they contain ribbon-like β-sheets in which the β-strands run approximately perpendicular to the long fibril axis and the inter-strand hydrogen bonds run approximately parallel the long fibril axis.
Negatively-stained TEM images of amyloid fibrils [1].
Any understanding of the properties and actions of amyloid protofibrils depends on knowledge of their molecular structure. Because amyloid protofibrils are inherently amorphous and insoluble, and are assembled from high molecular weight units, standard experimental methods for structure determination provide limited information. Due to the ineffectiveness of other methods and for various technical reasons, solid-state NMR spectroscopy has become the "method of choice" for amyloid structure determination.
Our Services
CD BioSciences offers services including real-time amyloid fibril localization, 3D structural imaging, and crystal structure analysis by combining powerful automated image acquisition and analysis with the help of our versatile microscopic instruments. Our microscopy systems provide you with intelligent innovations in structural imaging that can help you achieve optimal image quality.
- Multiple High Quality Structural Imaging Systems
- Amyloid Fibrils Structural Imaging for Different Tissues
- Amyloid Fibrils Structural Imaging in Different Disease Models
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Tycko R. Solid state NMR studies of amyloid fibril structure[J]. Annual review of physical chemistry, 2011, 62: 279.
For research use only. Not intended for any clinical use.
