The cytoskeleton is an indispensable cellular structure for cellular life activities, and the complex network system it forms plays an important role in cellular morphological changes and maintenance, cell division and differentiation, intracellular material transport, cellular information transfer and gene expression. CD BioSciences offers hundreds of compounds for cytoskeleton research. We actively follow the latest science, so our customers can rely on us to provide the latest types of cytoskeletal allosteric modulators.
What is an Allosteric Modulator?
Allosteric regulation refers to the ability of certain regulators to bind to the regulatory site of an enzyme to change the conformation of the enzyme molecule, thereby altering the enzyme activity. Some enzymes have one or several sites in addition to the active center, and when specific molecules bind non-covalently to these sites, they can change the conformation of the enzyme and thus the activity of the enzyme. This regulatory effect of enzymes is called allosteric regulation, and the enzymes subject to allosteric regulation are called allosteric enzymes, and these specific molecules are called effectors.
Allosteric regulation of epigenetic modifying enzymes [1].
Regulation of Cytoskeleton Allostery
After sensing mechanical stimulation, cells convert mechanical signals into chemical signals through certain signal transduction mechanisms, thus realizing their biological functions. The cytoskeleton across the cell acts as a hub in this series of signal transduction processes. In this series of signal transduction process, the cytoskeleton across the cell plays an important role as a pivot.
Common Cytoskeleton Associated Allosteric Modulators
| Name |
Target |
Description |
| Pi-analog vanadate |
Myosin |
The Pi-analog vanadate (Vi) is a nonspecific, competitive myosin inhibitor in the presence of ADP. |
| BDM |
Myosin |
2,3-butanedione monoxime (BDM), N-benzyl-p-toluenesulphonamide (BTS) and blebbistatin are inhibitors of class-2 myosins. The inhibitory effect of the low-affinity compound BDM is skeletal-muscle myosin-2 specific and associated with the allosteric inhibition of Pi release. |
| BTS |
| Blebbistatin |
| CCT |
CaSR |
CHX treatment increased cell proliferation, and long-term activation of CaSR with CCT disrupted the calmodulin-linked protein complex and induced cytoskeletal remodeling and actin fiber formation. |
| CHX |
Our Services
Allosteric modulators are often end products of metabolic pathways, and metabolic enzymes are often at the beginning of metabolic pathways. Through feedback inhibition, the entire metabolic pathway can be regulated early and unnecessary substrate consumption can be reduced. CD BioSciences provides screening services for cytoskeleton-targeted drugs and has a large library of compounds for cytoskeleton-related mechanistic studies and drug development.
- Customizable Compound Library for Cytoskeleton
To ensure you find the right allosteric modulators for your research and guarantee the success of your study Customers can build a library of suitable compounds for your research by selecting compounds from our inventory.
- Allosteric Modulator Screening for Cytoskeleton
We provide the ability to search for allosteric regulatory molecules and analyze structures, functions and other annotations through the Allosteric Database. Data analysis via the ASD can be used to investigate potential allosteric target molecules and to help our customers understand their structures and modify them to obtain new cytoskeletal allosteric drugs.
- Allosteric Modulator Screening for Microtubules
- Allosteric Modulator Screening for Actin
- Allosteric Modulator Screening for Intermediate filaments
Process of Allosteric Modulator Development
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Zucconi B E, et al. Allosteric regulation of epigenetic modifying enzymes[J]. Current opinion in chemical biology, 2017, 39: 109-115.
For research use only. Not intended for any clinical use.
