The cytoskeleton controls the morphological and dynamic characteristics of eukaryotic cells and plays an important role in maintaining cellular integrity. CD BioSciences uses actin structure imaging, labeling and detection research tools and technical resources to save you more time for research and new discoveries. Design and optimize your protocols for high-quality experimental data using powerful assay kits and imaging systems.
Structure of Actin and Actin Complexes
Actin is the most abundant protein in most eukaryotic cells. It is highly conserved and participates in more protein-protein interactions than any other known protein. These properties, together with its ability to change between monomeric (G-actin) and filamentous (F-actin) states under the control of nucleotide hydrolysis, ions and a large number of actin-binding proteins, make actin a key player in many fields.
- G-actin: Globular actin (G-actin) is the main component of the microfilament structure in the cytoskeleton and is monomeric in nature. ATP dissociates myosin from F-actin.
- F-actin: F-actin, also known as microfilament, is a fibrous structure of approximately 7 nm in diameter made up of actin monomers. Microfilaments can be assembled and de-assembled.
Actin Molecule
Vertebrates express three major actin isoforms, including three α isoforms in skeletal, cardiac and smooth muscle, and β and γ isoforms in non-muscle and muscle cells. The actin isoforms differ only in a few amino acids, with most variation occurring at the N terminus.
Actin belongs to a structural superfamily of glucokinase, hexokinase and Hsp70 proteins, and the Arp proteins and the prokaryotic actin-like proteins MreB and ParM are now also part of this superfamily. What these proteins have in common is that the 375 amino acid polypeptide chain of actin folds into two major alpha/beta structural domains.
Structures of the actin molecule and actin filament [1].
Our Services
CD BioSciences offers services including real-time actin localization, 3D structural imaging, and crystal structure analysis by combining powerful automated image acquisition and analysis with the help of our versatile microscopic instruments. Our microscopy systems provide you with intelligent innovations in structural imaging that can help you achieve optimal image quality.
- Multiple High Quality Structural Imaging Systems
- Actin Structural Imaging for Different Types of Cells
- Actin Structural Imaging in Different Stages of Cell Cycles
Our Advantages
Advanced Biotechnology
Customizable Designs
Competitive Pricing
Best After-sales Service
CD BioSciences has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with cytoskeleton-related research service. If you have any needs, please contact us.
Reference
- Pollard T D. Actin and actin-binding proteins[J]. Cold Spring Harbor perspectives in biology, 2016, 8(8): a018226.
For research use only. Not intended for any clinical use.
