Design of Synthetic Biomolecular Condensates for Cellular Engineering

Based on building blocks and genetic tools, CD BioSciences offers comprehensive services to design and construct synthetic biomolecular condensates with responsive properties and on-demand functions in bacteria and eukaryotic cells. These synthetic compartments can act as a signal transduction hub in artificial signaling circuits within living cells. Clearly, synthetic biomolecular condensates have unique advantages in the cellular engineering of living organisms. Synthetic biomolecular condensates with specific functions enable various aspects of cell engineering, including transcription factor aggregation, chromatin reorganization, and control of cell division. For example, based on CRISPR Cas9-based optogenetic technology, CasDrop can be used for controlled liquid phase condensation of various nuclear proteins at specific genomic loci.

Fig. 1. Engineering strategy for programmable functional synthetic condensates. (Dai Y, et al., 2023)

Customized Services

CD BioSciences is a leading company focused on biological research and innovation, offering comprehensive services to design synthetic biomolecular condensates for cellular engineering applications. Our solutions enable the control of cellular activities with precision and efficiency. With our extensive expertise and state-of-the-art technology, we offer tailored solutions to meet the diverse needs of our customers.

Our synthetic biomolecular condensates are widely used in the following areas of cell engineering:

• Chromatin Reconstruction
  We offer dvanced technologies to design synthetic biomolecular condensates that can modulate chromatin structure and organization. By pinpointing specific genomic loci, these synthetic condensates can bring distant genomic elements closer together to enable regulatory interactions and influence gene expression patterns.
• Transcription Factor Clustering
  We offer services to engineer synthetic biomolecular condensates that enable transcription factors to cluster on target promoters. Our engineered condensates have enhanced binding affinity to the target promoter.
• Control of Cell Division
  Our experts are using technologies such as optogenetics to develop synthetic biomolecular condensates that can precisely control the process of cell division. Our solutions help drive asymmetric division in model organisms such as E. coli and open the way to study the mechanism of cell division and design asymmetric cell division in various cell types.
• Modulation of Endogenous Protein Activity
  We offer a reliable platform to modulate cellular activity by isolating and manipulating endogenous proteins. Our platform enables precise control of cellular behavior and can be applied to a wide range of proteins and organisms, revolutionizing the fields of chemical genetics and optogenetics.

CD BioSciences provides professional solutions for the application of synthetic biomolecular condensates in cellular engineering, ensuring precise control of cellular behavior and function. By partnering with CD BioSciences, you have access to state-of-the-art tools and expert guidance to accelerate your research and innovation in cellular engineering. If you have any special requirements for our services, please feel free to contact us.