Centrosome dysfunction has been linked to a variety of human diseases, including cancer, microcephaly, ciliopathies, and neurodegenerative disorders. Abnormalities in centrosome number, structure, or function can lead to defects in cell division, cilia formation, and neuronal development, which can ultimately result in disease.

Mouse models have been instrumental in studying the connection between centrosome dysfunction and disease. By manipulating genes involved in centrosome function, researchers can create mouse models that recapitulate the human disease phenotype. These mouse models can be used to understand the underlying mechanisms of disease and to develop and test potential therapies. CD BioSciences offers centrosome-related mouse models for assisting scientists understand biological systems better and make greater breakthrough in therapeutic and diagnostic development of centrosome-related diseases.

If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.

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• C57BL/6NJ-Cspp1^em1(IMPC)J/Mmjax (Cat. No.: CLMM-00270001) Inquiry
• Product Overview: This CRISPR-generated knock-out mutant of the centrosome and spindle pole associated protein 1 (Cspp1) gene has been generated by the Knockout Mouse Phenotyping Program (KOMP2). Cspp1 encodes a protein that may play a role in cell-cycle-dependent microtubule organization.

• CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J (Cat. No.: CLMM-00270002) Inquiry
• Product Overview: Transgenic GFP-CETN2 mice express an enhanced green fluorescent protein-labeled human Centrin-2 (EGFP-CETN2) under the control of the chicken beta-actin promoter (with cytomegalovirus immediate early enhancer). These GFP-CETN2 mice allow fluorescent staining of the centrioles of the centrosome, and may be useful for studying mitosis, microtubule organization, cell-cycle regulation, signal transduction, transcription activation, cell migration, DNA damage repair, and cancer.

• C57BL/6J-Alms1^tvrm102/PjnMmjax (Cat. No.: CLMM-00270003) Inquiry
• Product Overview: These ENU-induced tvrm102 mice carry a mutation in the exon 6 splice donor site of the Alms1 gene and provide a model for Alstrom syndrome with progressive weight gain and slow photoreceptor degeneration.

• C57BL/6N-Tg(CAG-HIST1H2BB/mRFP,-Plk4/EYFP)39Dwc/J (Cat. No.: CLMM-00270004) Inquiry
• Product Overview: Plk4-OE transgenic mice can be used for conditional expression of a mouse Plk4 (polo like kinase 4) -EYFP fusion protein under the direction of the CAG promoter. Prior to cre exposure, mice express histone H2B-mRFP, following cre exposure mice express mouse Plk4 fused to EYFP. This strain may be useful in studies involved in the regulation of centrosome amplification.

• STOCK Nubp1^m1Nisw/J (Cat. No.: CLMM-00270005) Inquiry
• Product Overview: These mice carry ENU-induced mutations in Nubp1 (nucleotide binding protein 1)gene which is involved in regulation of centrosome dynamics and microtubule organization, and is essential for lung progenitor survival.

• B6.129-CDC25A^tm1Dvb/J (Cat. No.: CLMM-00270006) Inquiry
• Product Overview: This targeted mutation of the cell division cycle 25 homolog A (CDC25A) gene displays radiation-induced tumorigenesis and centrosome amplification in mouse embryonic fibroblasts and may be useful in studies of cell cycle regulation and cancer.

• C57BL/6NJ-Cep192^em1(IMPC)J/Mmjax (Cat. No.: CLMM-00270007) Inquiry
• Product Overview: This CRISPR-generated knock-out mutant of the centrosomal protein 192 (Cep192) gene has been generated by the Knockout Mouse Phenotyping Program (KOMP2). Cep192 encodes a protein required for mitotic centrosome and spindle assembly.

• B6.Cg-Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} Col1a1^{tm1(tetO-Plk4,-EYFP)Ahol}/J (Cat. No.: CLMM-00270008) Inquiry
• Product Overview: Plk4^Dox mice may be used to induce overexpression of Plk4 via a tetracycline-controlled transactivator protein system. These mice may be useful for studying the role of Plk4 in centriole biology and centrosome amplification in multiple cancers.

• C57BL/6NJ-Haus4^em1(IMPC)J/Mmjax (Cat. No.: CLMM-00270009) Inquiry
• Product Overview: This CRISPR-generated knock-out mutant of the HAUS augmin-like complex, subunit 4 (Haus4) gene has been generated by the Knockout Mouse Phenotyping Program (KOMP²) Haus4 encodes a protein that contributes to mitotic spindle assembly, maintenance of centrosome integrity, and completion of cytokinesis.

• STOCK Gt(ROSA)26Sor^{tm1(EGFP/CETN1)Sev} (Cat. No.: CLMM-00270010) Inquiry
• Product Overview: This ROSA-Neo-EGFP-CETN1 strain serves as a cre recombinase mediated, tissue specific centrosome indicator reporter strain: when crossed with a Cre recombinase strain, the floxed-STOP cassette is deleted and the GT(ROSA)26Sor promoter drives expression of EGFP/CETN1 in the cre-expressing cells.

• C57BL/6J-Ankrd26^em1Ahol/J (Cat. No.: CLMM-00270011) Inquiry
• Product Overview: Ankrd26- mice carry a CRISPR/cas9 generated deletion of exons 23-30 of the ankyrin repeat domain 26 (Ankrd26) gene. These mice may be useful for studying the role of Ankrd26 in centriole signaling related to centrosome amplification and polyploidy. This is important in the context of cancer pathogenesis and chronic liver disease.

• STOCK Kif11^tm1.1Nat/J (Cat. No.: CLMM-00270012) Inquiry
• Product Overview: Cre recombinase-mediated excision of floxed exons 5 and 6 in these Kif11 CKO mice creates a knock-out allele of the mouse Kif11 (kinesin family member 11) gene. Mutations in the human gene have been associated with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy, and mental retardation.

• B6.129-Aurka^tm1.1Tvd/J (Cat. No.: CLMM-00270013) Inquiry
• Product Overview: These floxed mice possess loxP sites flanking exon 2 of the Aurka gene and have applications in studies related to regulation of mitosis and carcinogenesis.

• B6;SJL-Plk4^em1Ahol/J (Cat. No.: CLMM-00270014) Inquiry
• Product Overview: Plk4 ^Δu mice carry a CRISPR/Cas9-made mutation that knocks out start codons of the Plk4 upstream open reading frames uORF1 and uORF2. These mice may be useful for studying the role of Plk4 in centriole biology, regulation of gametogenesis and centrosome amplification in multiple cancers.

• B6.129S4-Sgo1^{Gt(neo-btk)1Dai}/J (Cat. No.: CLMM-00270015) Inquiry
• Product Overview: The Sgo1 knockout allele abolishes expression of both the full-length (Sgo1) and shorter (sSgo1) isoforms of the Sgol1 locus. Because Sgol1 plays a central role in chromosome cohesion (sister chromatid cohesion) during mitosis by preventing premature dissociation of the cohesin complex from centromeres, these mice may be useful in studying centrosome dynamics, chromosome instability and tumorigenesis.

• STOCK Tg(CAG-Arl13b/mCherry)1Kvand Tg(CAG-EGFP/CETN2)3-4Jgg/KvandJ (Cat. No.: CLMM-00270016) Inquiry
• Product Overview: Arl13b-mCherry; Centrin2-GFP double transgenic mice express mCherry in cilia and EGFP in centrosomes making them useful when studying lineage specificity of primary cilia in the mouse embryo.

• B6.129P2(SJL)-Ttk^tm1.1Kops/JlmaJ (Cat. No.: CLMM-00270017) Inquiry
• Product Overview: Cre-inducible-Mps1-Knock-in-TA (CiMKi^TA) mice carry a Cre-inducible point mutation (T649A) in exon 17 of the Ttk protein kinase (Ttk) gene, expression of which is blocked by the presence of a loxP-flanked cDNA cassette encoding exons 17-22 and a stop codon. This mutation results in a mutant protein similar to that found in human cell lines with a mild chromosomal instability (CIN) phenotype. This strain may be useful when studying oncogenic potential due to the degree and site of chromosomal instability.

• B6.129P2(SJL)-Ttk^tm2.1Kops/JlmaJ (Cat. No.: CLMM-00270018) Inquiry
• Product Overview: Cre-inducible-Mps1-Knock-in-KD (CiMKi^KD) mice carry a Cre-inducible point mutation (D637A) in exon 17 of the Ttk protein kinase (Ttk) gene, expression of which is blocked by the presence of a loxP-flanked cDNA cassette encoding exons 17-22 and a stop codon. This mutation results in a kinase dead protein similar to that found in human cell lines with a severe chromosomal instability (CIN) phenotype. This strain may be useful when studying oncogenic potential due to the degree and site of chromosomal instability.