Centrosomal mRNA-related Services
InquiryCentrosomal mRNA is mRNAs that localized near centrosomal that influence enrichment of pericentriolar material (PCM), as well as its function. CD BioSciences offers high-quality and professional services associated with centrosome research. With advanced technology, cutting edge equipment and experienced scientists, we have assisted our global customers in the field of centrosome research.
Overview of Centrosome
In animal cell, centrosome is the organelle that serves as the main microtube organizing center (MTOC), which promotes the formation of bipolar mitotic spindles and supplies the primary cilia matrix in various cells. In addition to the structural functions, they are also involved in many essential signaling hubs, such as cell cycle control, cytokinesis and mitotic exit, intracellular trafficking and genotoxic stress.
mRNAs in Centrosome
Centrosome is composed with an ordered matrix of proteins organized around a central pair of centrioles, as well as mRNAs. Although the RNAs localized as pericentriolar material (PCM) were identified decades ago, majority of them still remain to be characterized and functional studied. With the development of high-throughput screening methods, the identification of centrosomal RNAs has been accelerated, as well as their functional studies.
Centrosome has been proven to be site for local protein synthesis due to the studies that indicate the biological significance of centrosomal RNAs. Distinct RNA localization and translational activities is likely to be of great value in cell biology. Many of them show unique distributions that correlate with cell cycle stage, and there is bias of these centrosomal mRNAs in different stages of mitosis. The localization of centrosomal mRNA is infected by RNA-binding protein, such as CPEB bind with cyc B mRNA, which regulates the enrichment of centrosomal mRNAs and influence the spindle morphogenesis and mitotic process. Here is the list of conserved centrosomal mRNAs.
| Gene name (synonyms) | Species |
|---|---|
| abnormal spindle-like microcephaly associated (ASPM/asp) | human, Drosophila |
| BICD cargo adaptor 1 (BICD1/BicD) | human, Drosophila |
| centrocortin (cen) | Drosophila |
| cyclin B (CCNB1/cyc B) | Drosophila, Xenopus |
| hyaluronan-mediated motility receptor (HMMR) | human, Xenopus |
| ninein (NIN) | human, Drosophila, Xenopus |
| nuclear mitotic apparatus protein 1 (NUMA1) | human, Xenopus |
| pericentrin (PCNT/PLP) | human, Drosophila, zebrafish |
Our Services
CD BioSciences provides comprehensive and professional centrosomal mRNA related services, as well as customized services based on our years of experience and advanced technology. Services we provide are included but not limited as follows.
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With skilled and experienced genomics and cytology experts, state-of-the-art equipment and advanced technology, CD BioSciences offers customer all over the word services related to fields of centrosomal research. Our one-stop service program is your best assistant to accelerate you process of centrosomal research. Please feel free to contact us and get started with our high-quality services.
Reference
- Lerit DA. Signed, sealed, and delivered: RNA localization and translation at centrosomes. Mol Biol Cell. 2022 May 1;33(5):pe3.
Our services are for research use only and not for any clinical use.
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