Cat#: CCR-0071
(E)-Cyclooct-4-enol
Synonyms (s): (4E)-4-Cycloocten-1-ol, trans-Cyclooctenol, TCO-OH, rel-(1R,4E,pR)-Cyclooct-4-enol
Empirical Formula (Hill Notation): C8H14O
Size: 10 mg; 50 mg
Product Introduction
| Molecular Weight | 126.20 |
| NACRES | NA.22 |
| CAS Number | 85081-69-2 |
| PubChem Substance ID | 329767115 |
| Form | Liquid |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O[C@H]1CC/C=C/CCC1 |
| InChI | 1S/C8H14O/c9-8-6-4-2-1-3-5-7-8/h1-2,8-9H,3-7H2/b2-1+/t8-/m0/s1 |
| InChI key | UCPDHOTYYDHPEN-CMLYIYFCSA-N |
| Storage Temp. | -20 °C |
Application
(E)-Cyclooct-4-enol may be used in the multi-step synthesis of trans-cyclooctene geranyl diphosphate, a novel strained-ring containing protein farnesyltransferase (PFTase) substrate that can be used in site-specific modification technologies.
Hydroxyl modified cyclooctene derivative. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.
Safety Information
| Signal Word | Danger |
| Hazard Classifications | H318 |
| Storage Class Code | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
