Condensate-Based Drug Discovery Platform

Biomolecular condensates are formed by liquid-liquid phase separation (LLPS) and bind RNA and proteins into well-defined dynamic structures that are distinct from the surrounding cellular environment. Many physiological and pathogenic processes are associated with biomolecular condensates. CD BioSciences offers a comprehensive service to analyze the pathological function of biomolecular condensates, including characterization of LLPS and condensates in neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases.

To translate our knowledge of biomolecular condensates and their relationship to disease into condensate-modified therapeutics, CD BioSciences is creating a condensate-based drug discovery platform to develop innovative therapeutics for difficult-to-treat diseases. The platform can be divided into three main components:

Fig. 1. Condensate-based drug discovery platform.

The purpose of our condensate-based drug discovery platform:

Like many new technologies such as protein degradation, gene editing, and targeted RNA modulation, our condensate-based drug discovery platform is designed to provide new drug development strategies for "non-druggable" drug targets.

Advantages of our condensate-based drug discovery platform:

Our lab has cutting-edge interdisciplinary experimental techniques, computational technologies, and artificial intelligence to advance condensate-based drug discovery in a rapid manner, from target selection and lead compound optimization to clinical development.

Technical highlights of our condensate-based drug discovery platform:

• Disruption of pathological condensates produced by mutant proteins or RNAs offers new opportunities for treating disease.
• The use of condensates to address difficult drug therapy targets lacking binding pockets is functionally dependent on phase separation.
• Condensates-resident small molecules, RNA therapeutics and DNA editing show unexpected pharmacology.

CD BioSciences' condensate-based drug discovery platform is built on existing as well as new interdisciplinary assays. Each project will be individually designed to meet the client's requirements and described in a detailed project report. If you are interested in our solutions, please contact us.