Analysis of Biomolecular Condensates in Cell Competition, Fitness, and Aging

CD BioSciences is dedicated to the broad functional characterization of biomolecular condensates to develop a range of regulatory targets and approaches to provide new opportunities for drug development and clinical treatment of disease. Here, CD BioSciences offers professional services to analyze the function of biomolecular condensates in cell competition, fitness, and aging for the development of drug targets.

Introduction

Initially cellular fitness and cellular competition were usually considered as phenomena associated with cancer development. Currently cellular competition phenomena based on cellular fitness have more global significance as they are associated with normal cellular physiology, adaptability, survival and aging and represent intra-tissue homeostasis, tissue growth and regeneration, and general growth and development. In addition, cellular health and cellular competition are also associated with cellular aging, which is one of the fundamental features of multicellular life. These biological phenomena encompass a large number of extremely complex and highly intertwined processes and pathways that are undoubtedly essential for the maintenance of life. Studies have shown that liquid-liquid phase separation (LLPS) and various membraneless organelles (MLOs) are directly related to these phenomena.

Fig. 1. Hallmarks of ageing that may be associated with aberrant condensates. (Alberti S, et al., 2021)

Customized Services

Since LLPS and various MLOs represent cellular responses to stress or other stimuli that help cells survive and adapt, the biogenesis of MLOs is directly related to these processes. Our experts are very interested in the role of biomolecular condensates in aging, competition and fitness, and are trying to develop cutting-edge technologies to characterize their function.

Although the field of biological LLPS is still in its infancy and the available information on the role of this phenomenon in cellular fitness, cellular competition and cellular senescence is rather limited, LLPS and the resulting MLOs and biomolecular condensates may play multiple roles in these important processes. As one of the leading suppliers of biomolecular condensates, CD BioSciences is committed to exploring the role of LLPS and condensates in cellular fitness, cellular competition and cellular senescence to obtain more data on the complex connections between LLPS and these biological processes that define cell fate.

LLPS and MLOs, as manifestations of emergent behavior, bring stochasticity and complexity to the cellular competition and senescence processes. We aim to provide a more complete picture of important biological processes to develop therapeutic targets. We offer customized solutions to analyze phase separation in biological processes.

• Analysis of biomolecular cohesion in cell fitness
  Cellular fitness is a set of proteins encoded by adaptive genes that reflect a cell's ability to persist under specific conditions and is an important factor driving cellular competition. We can analyze the peer-mediated stress particle monitoring system that regulates MLOs composition and dynamics, and the relationship between the protein quality control (PQC) pathway and ribonucleoprotein (RNP) particles. We aim to develop targets for pathways and processes associated with MLOs and biomolecular condensates that influence and regulate cell fitness.
• Analysis of biomolecular condensates in cell competition
  Cell competition represents a specific, highly conserved type of cellular interaction that centers on assessing the relative fitness of a cell to its neighboring cells. We act as a trigger for cell competition by differentially modulating biomolecular condensates that are separated in LLPS and adjacent cells. Our data can provide an important link between cell competition triggered by significant differences in signaling levels between neighboring cells and the LLPS of many proteins associated with corresponding signaling pathways, including WNT/Wg, JAK-STAT and Hippo pathways, etc.
• Analysis of biomolecular condensates in cell senescence
  Most organisms undergo aging and there are nine preliminary senescence signatures that play a role in the time-dependent decline of organisms. We can analyze the proteins associated with senescence features that undergo LLPS and form liquid-like droplets, including the tumor antigen P53, COL17A, etc.

The three processes of cell competition, fitness and senescence include a large number of cellular pathways. Our service comprehensively analyzes the role in cellular adaptation, cellular competition and cellular senescence to develop therapeutic targets. If you have any special requirements for our services, please feel free to contact us. We are looking forward to working together with your attractive projects.