Product Size
25 mg
5 mg
Custom Size
Product Overview
Description
Potent, ATP-competitve PI3K inhibitor.
Biological Description
Potent, ATP-competitive PI3K inhibitor (IC50 values are 5, 16, 44 and 49 nM for PI3Kδ, PI3Kα, PI3Kβ and PI3Kγ respectively). Induces G1-phase arrest but not apoptosis. Shows potent antiproliferative effects. Shows antitumor effects in vivo. Orally active.
Solubility Overview
Soluble in DMSO to 50 mM.
Chemical Properties
Chemical Name
4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
Molecular Weight (Da)
417.41
Molecular Formula
C19H21F2N7O2
SMILES
C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
