Product Overview
Reactivity
Human, Mouse, Rat
Target Information
Alternative Names
DKFZp686F19106; DKFZp781H1112; FYVE domain-containing Centrosomal protein; FYVE-CENT; KIAA0321zinc finger FYVE domain-containing protein 26; spastic paraplegia 15 (complicated, autosomal recessive); spastizin; SPG15; zinc finger, FYVE domain containing 26
Function
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.
Tissue Specificity
Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Storage Buffer
PBS (pH 7.2) and 40% Glycerol.
Preservative
0.02% Sodium Azide
