Product Overview
Reactivity
Human, Mouse, Rat
Target Information
Alternative Names
hVPS4; Protein SKD2; SKD1; SKD1 homolog; SKD1A; SKD2; Vacuolar protein sorting 4 homolog A; Vacuolar protein sorting 4, yeast, homolog of, A; Vacuolar protein sorting factor 4A; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4; VPS4-1; Vps4a; VPS4A_HUMAN
Function
Involved in late steps of the endosomal multivesicular bodies pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding. Involved in cytokinesis.
Tissue Specificity
Ubiquitously expressed.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C long term. Avoid freeze / thaw cycle.
Storage Buffer
PBS, 50% Glycerol (glycerin, glycerine). pH: 7.30.
Preservative
0.02% Sodium Azide
