Product Overview
Description
Potent, cell permeable VHL inhibitor.
Biological Description
VH298 is a cell permeable compound that binds tightly to VHL (KD = 80- 90 nM in in vitro binding assays) leading to cellular accumulation of HIF1-α. VH298 selectively stabilizes hydroxylated HIF1-α and induces HIF-dependent transcription.
Solubility Overview
100 mM in DMSO; 100 mM in ethanol.
Chemical Properties
Chemical Name
(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular Weight (Da)
523.65
Molecular Formula
C27H33N5O4S
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C.
