Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, selective PPAR-γ receptor agonist.
Target
PPAR gamma receptor
Biological Description
Potent, selective PPAR-γ receptor agonist (EC50 = 780 nM). No activity at PPAR-α or PPAR-δ (up to 10 mM). Orally active. It has a role as a hypoglycemic agent, an antioxidant, a vasodilator agent, an anticonvulsant, an anticoagulant, a platelet aggregation inhibitor, an antineoplastic agent, an long-chain-fatty-acid--CoA ligase inhibitor, an antidiabetic agent, an anticancer agent and a ferroptosis inhibitor. Active in vivo and in vitro.
Solubility Overview
Soluble in ethanol to 10 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
5-[[4-[3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Molecular Weight (Da)
441.54
Molecular Formula
C24H27NO5S
SMILES
Cc1c(O)c(C)c(C)c2OC(C)(CCc12)COc4ccc(CC3SC(=O)NC3=O)cc4
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
