Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Selective CK2 inhibitor.
Biological Description
CK2 inhibitor (Ki = 0.25 μM), more selective than DMAT. Unlike DMAT, TMCB displays selectivity over PIM1, HIPK2 and DYRK1a (Ki values are 8.65, 15.25 and 11.90 μM, respectively) and a more favourable selectivity profile over a range of other kinases.
Solubility Overview
Soluble in DMSO to 25 mM (with heating).
Chemical Properties
Chemical Name
2-[4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl]acetic acid
Molecular Weight (Da)
534.82
Molecular Formula
C11H9Br4N3O2
SMILES
CN(C)c2nc1c(c(Br)c(Br)c(Br)c1Br)n2CC(=O)O
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
