Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
Irreversible selective and Potent inhibitor of CDK7.
Biological Description
A potent (IC50 = 15.6nM at 20 minutes) and selective inhibitor that combines allosteric covalent binding and ATP-site binding to irreversibly inhibit cyclin-dependent kinase 7 (CDK7). It demonstrates strong anti-proliferative effects across types of cancers and cell lines by disrupting transcription of several proteins and decreasing binding of STAT3 chromatin and target gene expression of genes such as MYC and PIM1.
Solubility Overview
Soluble in DMSO (up to at least 25 mg/mL).
Chemical Properties
Chemical Name
N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide
Molecular Weight (Da)
566.10
Molecular Formula
C31H28ClN7O2
SMILES
CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C long term. Store under desiccating conditions.
