Product Size
25 mg
5 mg
Custom Size
Product Overview
Description
Potent, selective ATP-competitive Clk1/Sty inhibitor.
Biological Description
Potent, selective ATP-competitive Clk1/Sty inhibitor (IC50 values are 20, 200, 15 nM and >10 μM for Clk1/Sty, Clk2, Clk4 and Clk3 respectively). Blocks alternative splicing of PKCβII and expression of PPARγ1 and PPARγ2. Shows analgesic effects in vivo. Centrally active.
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
Molecular Weight (Da)
249.33
Molecular Formula
C13H15NO2S
SMILES
CCN\1C2=C(C=CC(=C2)OC)S/C1=C\C(=O)C
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
