Temsirolimus (CCI779), mTORC1 Complex Inhibitor

Inquiry

Cat. No.

CLIA-0130001

Product Size

50 mg 10 mg Custom Size

Product Overview

Description

Selective mTORC1 complex inhibitor (IC50 = 1.76 µM).

Purity

> 98%

Form

Solid

Alternative Names

CCI-779; Torisel

Target

mTORC1

Biological Description

Selective mTORC1 complex inhibitor (IC50 = 1.76 µM). Water-soluble rapamycin pro-drug. Rapidly converts to rapamycin in vivo. Inhibits proliferation and angiogenesis and induces apoptosis and autophagy in vivo.

Source

Synthetic

CAS Number

162635-04-3

Solubility Overview

Soluble in ethanol to 100 mM and in DMSO to 100 mM.

Chemical Properties

Chemical Name

(1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

Molecular Weight (Da)

1030.29

Molecular Formula

C₅₆H₈₇NO₁₆

PubChem Identifier

6918289

SMILES

CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC

Storage & Handling

Storage Instructions

Store at -20 °C. The product can be stored for up to 12 months.

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.